ID   U16_HHV6G               Reviewed;         334 AA.
AC   P30024; Q9DYD9;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=Protein U17/U16;
GN   Name=U17/U16;
OS   Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10369;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1310766; DOI=10.1128/jvi.66.3.1564-1570.1992;
RA   Geng Y., Chandran B., Josephs S.F., Wood C.;
RT   "Identification and characterization of a human herpesvirus 6 gene segment
RT   that trans activates the human immunodeficiency virus type 1 promoter.";
RL   J. Virol. 66:1564-1570(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING (ISOFORMS 2 AND
RP   3).
RX   PubMed=11069999; DOI=10.1128/jvi.74.23.11040-11054.2000;
RA   Flebbe-Rehwaldt L.M., Wood C., Chandran B.;
RT   "Characterization of transcripts expressed from human herpesvirus 6A strain
RT   GS immediate-early region B U16-U17 open reading frames.";
RL   J. Virol. 74:11040-11054(2000).
CC   -!- FUNCTION: Isoform 3 can transactivate the human immunodeficiency virus
CC       type 1 promoter.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=Protein U17/U16;
CC         IsoId=P30024-1; Sequence=Displayed;
CC       Name=2; Synonyms=Protein U17;
CC         IsoId=Q9DYE0-1; Sequence=External;
CC       Name=3; Synonyms=Protein U16, B701;
CC         IsoId=P30024-2; Sequence=VSP_034773;
CC   -!- PTM: Isoform 1 is not glycosylated.
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG30203.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; M81789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF294810; AAG30203.1; ALT_SEQ; Genomic_DNA.
DR   PIR; A42186; WMBE6H.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 1.
PE   3: Inferred from homology;
KW   Activator; Alternative splicing; Transcription; Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Protein U17/U16"
FT                   /id="PRO_0000116333"
FT   VAR_SEQ         1..191
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034773"
FT   CONFLICT        36
FT                   /note="Y -> C (in Ref. 2; AAG30203)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   334 AA;  38445 MW;  CAC6925264245C84 CRC64;
     MADERTGDSV KTRYDIALMN LNDIKIAVFR DSLSTYVEQK TGLTIQFNWP KSRCLVISTL
     CKIPFPTKSA AELQEMCSLL LCCPERLQLL GYVSVWGEET RDVCLTKTLV FAGEDEKFYG
     LDFVNETLYL LAETTERFAV LGLRRYDPVY REKDIRFLTK IDDVLQSLID AQDNLWKFAT
     IVYKNSGRHY IMKSCLENND GVFVLFLTRK EDFPSRMEWN FFSDVYESMP YHGQVIGSIG
     KTLLYPKTMF VMMDLSGAIY GIDTIGTGIG SCVKIADDFE SFLRQGIVRG YRRYKFFHRN
     ISTVQEILPL CPHTSLGPTF SNNYNYDLSS EDDE