ID   U16_HHV6U               Reviewed;         334 AA.
AC   Q69551; Q76VQ2; Q89432;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   02-JUN-2021, entry version 58.
DE   RecName: Full=Protein U17/U16;
GN   Name=U17/U16;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING (ISOFORMS 2 AND
RP   3).
RX   PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA   Nicholas J., Martin M.E.D.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT   of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT   homologs and transactivating functions.";
RL   J. Virol. 68:597-610(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: Isoform 3 can transactivate the human immunodeficiency virus
CC       type 1 promoter. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=Protein U17/U16, Protein U16exon1-2;
CC         IsoId=Q69551-1; Sequence=Displayed;
CC       Name=2; Synonyms=Protein U17, EFLF1;
CC         IsoId=Q69552-1; Sequence=External;
CC       Name=3; Synonyms=Protein U16, EFLF2;
CC         IsoId=Q69551-2; Sequence=VSP_034621;
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16721.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA58395.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA58396.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; M81789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; L25528; AAA16721.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; X83413; CAA58395.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; X83413; CAA58396.1; ALT_SEQ; Genomic_DNA.
DR   PIR; T09308; T09308.
DR   PRIDE; Q69551; -.
DR   Proteomes; UP000009295; Genome.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 1.
PE   3: Inferred from homology;
KW   Activator; Alternative splicing; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..334
FT                   /note="Protein U17/U16"
FT                   /id="PRO_0000343647"
FT   VAR_SEQ         1..191
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034621"
FT   CONFLICT        226
FT                   /note="Y -> C (in Ref. 1; M81789)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        232
FT                   /note="D -> H (in Ref. 1; M81789)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        302
FT                   /note="N -> S (in Ref. 1; M81789)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        325
FT                   /note="I -> N (in Ref. 1; M81789)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   334 AA;  38493 MW;  9627082A31D3CECA CRC64;
     MADERTSDSV KTRYDIALMK LNDIKIAVFR DSLSTYVEQK TGLTIQFNWP KSRCLVISTL
     CKIPFPTKSA AELQEMCSLL LCCPERLQLL GYVSVWGEET RDVCLTKTLV FAGEDEKFYG
     LDFVNETLYL LAETTERFAV LGLRRYDPVY REKDIRFLTK IDDVLQSLID AQDNLWKFAT
     IVYKNSGRHY IMKSCLENND GVFVLFLTRK EDFPSRMEWN FFSDVYESMP YDGQVIGSIG
     KTLLYPKTMF VMMDLSGAIY GIDTIGTGIG SCVKIADDFE SFLRQGIVRG YRRYKFFHRN
     INTVQEILPL CPHTSLGPTF SNNYIYDLSS EDDE