U17L7_HUMAN
ID U17L7_HUMAN Reviewed; 530 AA.
AC P0C7H9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7;
GN Name=USP17L7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NOMENCLATURE.
RX PubMed=15780755; DOI=10.1016/j.ygeno.2004.11.013;
RA Burrows J.F., McGrattan M.J., Johnston J.A.;
RT "The DUB/USP17 deubiquitinating enzymes, a multigene family within a
RT tandemly repeated sequence.";
RL Genomics 85:524-529(2005).
RN [3]
RP NOMENCLATURE.
RX PubMed=17109758; DOI=10.1186/1471-2164-7-292;
RA Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.;
RT "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family
RT members associated with cell viability.";
RL BMC Genomics 7:292-292(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase C19 family. USP17 subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: The RS447 megasatellite DNA is a highly polymorphic conserved
CC tandem repetitive sequence which contains a copy of the USP17 gene. It
CC is present with an interindividual variation in copy number, ranging
CC from 20 to 103, and can be found in the genome both on chromosome 4 and
CC chromosome 8. The high similarity between the UPS17-like genes makes
CC impossible to clearly assign data to one of the genes of the family.
CC Oligonucleotides designed in RNAi experiments are for instance not
CC specific of a given UPS17-like gene. {ECO:0000305}.
CC -!- CAUTION: Phe-89 is present instead of the conserved Cys which is
CC expected to be an active site residue suggesting that this protein has
CC lost its catalytic activity. {ECO:0000305}.
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DR EMBL; AC130366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS78305.1; -.
DR RefSeq; NP_001243798.1; NM_001256869.1.
DR AlphaFoldDB; P0C7H9; -.
DR SMR; P0C7H9; -.
DR BioGRID; 134130; 5.
DR IntAct; P0C7H9; 3.
DR STRING; 9606.ENSP00000485337; -.
DR MEROPS; C19.984; -.
DR BioMuta; USP17L7; -.
DR DMDM; 187653908; -.
DR PeptideAtlas; P0C7H9; -.
DR PRIDE; P0C7H9; -.
DR ProteomicsDB; 52335; -.
DR Antibodypedia; 74359; 9 antibodies from 5 providers.
DR DNASU; 392197; -.
DR Ensembl; ENST00000530447.5; ENSP00000485337.2; ENSG00000226430.7.
DR GeneID; 392197; -.
DR KEGG; hsa:392197; -.
DR MANE-Select; ENST00000530447.5; ENSP00000485337.2; NM_001256869.2; NP_001243798.1.
DR UCSC; uc031tag.2; human.
DR CTD; 392197; -.
DR DisGeNET; 392197; -.
DR GeneCards; USP17L7; -.
DR HGNC; HGNC:37180; USP17L7.
DR HPA; ENSG00000226430; Not detected.
DR neXtProt; NX_P0C7H9; -.
DR OpenTargets; ENSG00000226430; -.
DR VEuPathDB; HostDB:ENSG00000226430; -.
DR eggNOG; KOG1865; Eukaryota.
DR GeneTree; ENSGT00940000161948; -.
DR HOGENOM; CLU_008279_10_0_1; -.
DR InParanoid; P0C7H9; -.
DR OMA; HAGWICH; -.
DR OrthoDB; 561804at2759; -.
DR PhylomeDB; P0C7H9; -.
DR PathwayCommons; P0C7H9; -.
DR BioGRID-ORCS; 392197; 11 hits in 179 CRISPR screens.
DR GenomeRNAi; 392197; -.
DR Pharos; P0C7H9; Tdark.
DR PRO; PR:P0C7H9; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; P0C7H9; protein.
DR Bgee; ENSG00000226430; Expressed in sural nerve and 3 other tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0016579; P:protein deubiquitination; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Nucleus; Reference proteome.
FT CHAIN 1..530
FT /note="Inactive ubiquitin carboxyl-terminal hydrolase 17-
FT like protein 7"
FT /id="PRO_0000331649"
FT DOMAIN 80..375
FT /note="USP"
FT REGION 382..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 161
FT /note="A -> G (in dbSNP:rs17815120)"
FT /id="VAR_051526"
FT VARIANT 494
FT /note="P -> L (in dbSNP:rs9694759)"
FT /id="VAR_051527"
SQ SEQUENCE 530 AA; 59751 MW; E748553538E9AFA3 CRC64;
MEDDSLYLGG DWQFNHFSKL TSSRLDAAFA EIQRTSLSEK SPLSSETRFD LCDDLAPVAR
QLAPREKLPL SSRRPAAVGA GLQKIGNTFY VNVSLQCLTY TLPLSNYMLS REDSQTCHLH
KCCMFCTMQA HITWALHSPG HVIQPSQVLA AGFHRGEQED AHEFLMFTVD AMKKACLPGH
KQLDHHSKDT TLIHQIFGAY WRSQIKYLHC HGVSDTFDPY LDIALDIQAA QSVKQALEQL
VKPKELNGEN AYHCGLCLQK APASKTLTLP TSAKVLILVL KRFSDVTGNK LAKNVQYPKC
RDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD DAEVTASGIT
SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RPATQGELKR DHPCLQVPEL
DEHLVERATQ ESTLDHWKFP QEQNKTKPEF NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP
EQQSSLLNLS STKPTDQESM NTGTLASLQG STRRSKGNNK HSKRSLLVCQ
