ID   U17L8_HUMAN             Reviewed;         530 AA.
AC   P0C7I0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8;
GN   Name=USP17L8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=15780755; DOI=10.1016/j.ygeno.2004.11.013;
RA   Burrows J.F., McGrattan M.J., Johnston J.A.;
RT   "The DUB/USP17 deubiquitinating enzymes, a multigene family within a
RT   tandemly repeated sequence.";
RL   Genomics 85:524-529(2005).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=17109758; DOI=10.1186/1471-2164-7-292;
RA   Shin J.-M., Yoo K.-J., Kim M.-S., Kim D., Baek K.-H.;
RT   "Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family
RT   members associated with cell viability.";
RL   BMC Genomics 7:292-292(2006).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family. USP17 subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: The RS447 megasatellite DNA is a highly polymorphic conserved
CC       tandem repetitive sequence which contains a copy of the USP17 gene. It
CC       is present with an interindividual variation in copy number, ranging
CC       from 20 to 103, and can be found in the genome both on chromosome 4 and
CC       chromosome 8. The high similarity between the UPS17-like genes makes
CC       impossible to clearly assign data to one of the genes of the family.
CC       Oligonucleotides designed in RNAi experiments are for instance not
CC       specific of a given UPS17-like gene. {ECO:0000305}.
CC   -!- CAUTION: Tyr-334 is present instead of the conserved His which is
CC       expected to be an active site residue suggesting that this protein has
CC       lost its catalytic activity. {ECO:0000305}.
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DR   EMBL; AC130365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS78300.1; -.
DR   RefSeq; NP_001243801.1; NM_001256872.1.
DR   AlphaFoldDB; P0C7I0; -.
DR   SMR; P0C7I0; -.
DR   STRING; 9606.ENSP00000485306; -.
DR   MEROPS; C19.986; -.
DR   iPTMnet; P0C7I0; -.
DR   PhosphoSitePlus; P0C7I0; -.
DR   BioMuta; USP17L8; -.
DR   DMDM; 187653909; -.
DR   PeptideAtlas; P0C7I0; -.
DR   PRIDE; P0C7I0; -.
DR   DNASU; 392188; -.
DR   Ensembl; ENST00000527080.1; ENSP00000485306.1; ENSG00000237038.5.
DR   GeneID; 392188; -.
DR   KEGG; hsa:392188; -.
DR   MANE-Select; ENST00000527080.1; ENSP00000485306.1; NM_001256872.1; NP_001243801.1.
DR   UCSC; uc031tae.1; human.
DR   CTD; 392188; -.
DR   GeneCards; USP17L8; -.
DR   HGNC; HGNC:37181; USP17L8.
DR   HPA; ENSG00000237038; Not detected.
DR   neXtProt; NX_P0C7I0; -.
DR   VEuPathDB; HostDB:ENSG00000237038; -.
DR   eggNOG; KOG1865; Eukaryota.
DR   GeneTree; ENSGT00940000161948; -.
DR   HOGENOM; CLU_008279_10_0_1; -.
DR   InParanoid; P0C7I0; -.
DR   OMA; GENAYPC; -.
DR   OrthoDB; 561804at2759; -.
DR   PhylomeDB; P0C7I0; -.
DR   PathwayCommons; P0C7I0; -.
DR   Reactome; R-HSA-5689880; Ub-specific processing proteases.
DR   BioGRID-ORCS; 392188; 8 hits in 178 CRISPR screens.
DR   GenomeRNAi; 392188; -.
DR   Pharos; P0C7I0; Tdark.
DR   PRO; PR:P0C7I0; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; P0C7I0; protein.
DR   Bgee; ENSG00000237038; Expressed in developing anatomical structure and 1 other tissue.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0016579; P:protein deubiquitination; IBA:GO_Central.
DR   GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Nucleus; Reference proteome.
FT   CHAIN           1..530
FT                   /note="Inactive ubiquitin carboxyl-terminal hydrolase 17-
FT                   like protein 8"
FT                   /id="PRO_0000331650"
FT   DOMAIN          80..375
FT                   /note="USP"
FT   REGION          382..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          493..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..512
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   530 AA;  59635 MW;  CD04444E832EE911 CRC64;
     MEDDSLYLGG EWQFNHFSKL TSPRPDAAFA EIQRTSLPEK SPLSSETRVD LCDDLAPVAR
     QLAPREKLPL SSRRPAAVGA GLQNMGNTCY LNASLQCLTY TPPLANYMLS REHSQTCQRP
     KCCMLCTMQA HITWALHSPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMKKACLPGH
     KQVDHHSKDT TLIHQIFGGC WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVKQALEQL
     VKPEELNGEN AYPCGLCLQR APASNTLTLH TSAKVLILVL KRFCDVTGNK LAKNVQYPEC
     LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGYYFSYVK AQEGQWYKMD DAEVTACSIT
     SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RPATQGELKR DHPCLQVPEL
     DEHLVERATE ESTLDHWKFP QEQNKMKPEF NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP
     EQQSSLLNLS SMNSTDQESM NTGTLASLQG RTRRSKGKNK HSKRSLLVCQ