ID   U17LN_HUMAN             Reviewed;         183 AA.
AC   D6RBM5;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23;
GN   Name=USP17L23;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C19 family. USP17 subfamily.
CC       {ECO:0000305}.
CC   -!- CAUTION: The RS447 megasatellite DNA is a highly polymorphic conserved
CC       tandem repetitive sequence which contains a copy of USP17. It is
CC       present with an interindividual variation in copy number and between 20
CC       to 103 copies can be found on chromosome 4 and chromosome 8.
CC       {ECO:0000305}.
CC   -!- CAUTION: Product of a dubious gene prediction. {ECO:0000305}.
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DR   EMBL; AC108519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; D6RBM5; -.
DR   SMR; D6RBM5; -.
DR   STRING; 9606.ENSP00000424077; -.
DR   MEROPS; C19.987; -.
DR   BioMuta; USP17L23; -.
DR   PaxDb; D6RBM5; -.
DR   PeptideAtlas; D6RBM5; -.
DR   PRIDE; D6RBM5; -.
DR   Ensembl; ENST00000506619.2; ENSP00000424077.2; ENSG00000250913.2.
DR   UCSC; uc062vda.1; human.
DR   GeneCards; USP17L23; -.
DR   HGNC; HGNC:44451; USP17L23.
DR   HPA; ENSG00000250913; Not detected.
DR   neXtProt; NX_D6RBM5; -.
DR   VEuPathDB; HostDB:ENSG00000250913; -.
DR   eggNOG; KOG1865; Eukaryota.
DR   GeneTree; ENSGT00940000161948; -.
DR   HOGENOM; CLU_1261126_0_0_1; -.
DR   InParanoid; D6RBM5; -.
DR   OMA; ACWHEDR; -.
DR   PhylomeDB; D6RBM5; -.
DR   Pharos; D6RBM5; Tdark.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; D6RBM5; protein.
DR   Bgee; ENSG00000250913; Expressed in sural nerve and 26 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   5: Uncertain;
KW   Endoplasmic reticulum; Nucleus; Reference proteome.
FT   CHAIN           1..183
FT                   /note="Putative ubiquitin carboxyl-terminal hydrolase 17-
FT                   like protein 23"
FT                   /id="PRO_0000421097"
FT   DOMAIN          80..183
FT                   /note="USP"
SQ   SEQUENCE   183 AA;  20302 MW;  B29AAD40CE5A5DE7 CRC64;
     MEDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD LCDDLAPVAR
     QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY TPPLANYMLS REHSQTCHRH
     KGCMLCTMQA HITRALHNPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMEKACLPGH
     KQV