ID   U18_HHV6Z               Reviewed;         294 AA.
AC   Q9WT46; Q77PV4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   02-JUN-2021, entry version 50.
DE   RecName: Full=Putative immediate early glycoprotein;
DE   AltName: Full=Protein U18;
DE   Flags: Precursor;
GN   Name=U18;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HST;
RX   PubMed=10482554; DOI=10.1128/jvi.73.10.8053-8063.1999;
RA   Isegawa Y., Mukai T., Nakano K., Kagawa M., Chen J., Mori Y., Sunagawa T.,
RA   Kawanishi K., Sashihara J., Hata A., Zou P., Kosuge H., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of human herpesvirus 6 variants A
RT   and B.";
RL   J. Virol. 73:8053-8063(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae immediate early glycoprotein
CC       family. {ECO:0000305}.
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DR   EMBL; AF157706; AAD49630.1; -; Genomic_DNA.
DR   EMBL; AB021506; BAA78239.1; -; Genomic_DNA.
DR   PIR; T43978; T43978.
DR   RefSeq; NP_050198.1; NC_000898.1.
DR   PRIDE; Q9WT46; -.
DR   DNASU; 1497014; -.
DR   GeneID; 1497014; -.
DR   KEGG; vg:1497014; -.
DR   Proteomes; UP000006930; Genome.
DR   Proteomes; UP000142685; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR010880; Herpes_UL37_HHV-5-rel.
DR   Pfam; PF07413; Herpes_UL37_2; 1.
PE   3: Inferred from homology;
KW   Host membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..294
FT                   /note="Putative immediate early glycoprotein"
FT                   /id="PRO_0000408421"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   294 AA;  33036 MW;  8D7E9AEB76BD876E CRC64;
     MKKLTMESLL VYTFVMGVCF TSNLTCEQKI VLIQEQKLGA ICISTCYVNG VLAGNSSCVS
     VRTSYLINLA MLTDGFKAMK VGNITSISEK TAFLRVIINY YFRGVMLRAL IAKRLPNAAQ
     LSSTVNCWLE GHSAGGVMTL FYGTERIVLK SSTEMNASQW TSDGPDANGT LNILNERVSL
     DSYFLSMICP QLSDEIYKKK VVHSKYFSLI KNDTMPKKFL RNTWKSAWTN WYKYKEIEAL
     LDFSRDYENV SEITHSMSAA GLFFLAGGAF TMLLLLCCLS MITRKHVVKD LGYK