ID   U19BB_XENLA             Reviewed;         241 AA.
AC   Q6INE2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Protein unc-119 homolog B-B;
GN   Name=unc119b-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Myristoyl-binding protein that acts as a cargo adapter:
CC       specifically binds the myristoyl moiety of a subset of N-terminally
CC       myristoylated proteins and is required for their localization. Plays a
CC       key role in localization of proteins to the primary cilium membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- DOMAIN: Adopts an immunoglobulin-like beta-sandwich fold forming a
CC       hydrophobic cavity that capture N-terminally myristoylated target
CC       peptides. Phe residues within the hydrophobic beta sandwich are
CC       required for myristate binding (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PDE6D/unc-119 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC072341; AAH72341.1; -; mRNA.
DR   RefSeq; NP_001085421.1; NM_001091952.1.
DR   AlphaFoldDB; Q6INE2; -.
DR   DNASU; 443847; -.
DR   GeneID; 443847; -.
DR   KEGG; xla:443847; -.
DR   CTD; 443847; -.
DR   Xenbase; XB-GENE-981107; unc119b.S.
DR   OrthoDB; 1270912at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 443847; Expressed in blastula and 18 other tissues.
DR   GO; GO:0035869; C:ciliary transition zone; ISS:UniProtKB.
DR   GO; GO:0008289; F:lipid binding; ISS:UniProtKB.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0042953; P:lipoprotein transport; ISS:UniProtKB.
DR   Gene3D; 2.70.50.40; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR008015; PDED_dom.
DR   InterPro; IPR037036; PDED_dom_sf.
DR   Pfam; PF05351; GMP_PDE_delta; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Lipid-binding;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..241
FT                   /note="Protein unc-119 homolog B-B"
FT                   /id="PRO_0000337232"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         132
FT                   /ligand="tetradecanoate"
FT                   /ligand_id="ChEBI:CHEBI:30807"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   241 AA;  27870 MW;  A3D6ACD1901A6EAF CRC64;
     MSGSNREAAL AGQPKDERKK SGGGVINRLK ARRVQGKESG TSDQSSITRF REEELLGLNE
     LRPEHVLGLS RVTDNYLCKP EDNIFGIDFT RFKIRDLETG TVLFEISKPC SEQEEEEEST
     HLDASAGRFV RYQFTPAFLR LRKVGATVEF TVGDKPVKSF RMIERHYFRD RILKSFDFDF
     GFCIPNSRNT CEHMYEFPQL SEELIRLMTE NPYETRSDSF YFVDNKLIMH NKADYAYNGG
     Q