U1SBP_BOVIN
ID U1SBP_BOVIN Reviewed; 245 AA.
AC Q1LZH0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=U11/U12 small nuclear ribonucleoprotein 35 kDa protein;
DE Short=U11/U12 snRNP 35 kDa protein;
DE AltName: Full=U1 snRNP-binding protein homolog;
GN Name=SNRNP35; Synonyms=U1SNRNPBP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; BC116002; AAI16003.1; -; mRNA.
DR RefSeq; NP_001069024.1; NM_001075556.2.
DR RefSeq; XP_005217863.1; XM_005217806.1.
DR AlphaFoldDB; Q1LZH0; -.
DR SMR; Q1LZH0; -.
DR STRING; 9913.ENSBTAP00000043747; -.
DR PaxDb; Q1LZH0; -.
DR PRIDE; Q1LZH0; -.
DR Ensembl; ENSBTAT00000010602; ENSBTAP00000043747; ENSBTAG00000008060.
DR GeneID; 512142; -.
DR KEGG; bta:512142; -.
DR CTD; 11066; -.
DR VEuPathDB; HostDB:ENSBTAG00000008060; -.
DR VGNC; VGNC:35070; SNRNP35.
DR eggNOG; KOG0113; Eukaryota.
DR GeneTree; ENSGT00940000157648; -.
DR HOGENOM; CLU_035088_1_0_1; -.
DR InParanoid; Q1LZH0; -.
DR OMA; FEHERDF; -.
DR OrthoDB; 1430110at2759; -.
DR TreeFam; TF331614; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000008060; Expressed in pons and 103 other tissues.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0017069; F:snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12237; RRM_snRNP35; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034146; snRNP35_RRM.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; RNA-binding; Spliceosome; Ubl conjugation.
FT CHAIN 1..245
FT /note="U11/U12 small nuclear ribonucleoprotein 35 kDa
FT protein"
FT /id="PRO_0000307906"
FT DOMAIN 51..129
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 146..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 172
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q16560"
SQ SEQUENCE 245 AA; 29294 MW; 8D5D885BCBEEAFD2 CRC64;
MNDWMPIAKE YDPLKAGSID GTDEDPHDRA VWRAMLARYT PNKGVTGDPL LTLFVARLNL
QTKEEKLKEV FSRYGDIRRL RLVRDLVTGF SKGYAFIEYK DERSLLKAYR DADGLVIDQH
EIFVDYELER TLKGWIPRRL GGGLGGKKES GQLRFGGRDR PFRKPINLPV VKNDQFREGK
RERRERSRSR ERHWDSRMRD HHDRGREKRW QEREPARAWP EGDWERERDF RDDRVKGREK
RDRSK
