U1SBP_MOUSE
ID U1SBP_MOUSE Reviewed; 244 AA.
AC Q9D384; Q8CAC7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=U11/U12 small nuclear ribonucleoprotein 35 kDa protein;
DE Short=U11/U12 snRNP 35 kDa protein;
DE AltName: Full=U1 snRNP-binding protein homolog;
GN Name=Snrnp35; Synonyms=U1snrnpbp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Component of the U11/U12 snRNPs that are part of the U12-type
CC spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AK018232; BAB31127.1; -; mRNA.
DR EMBL; AK039064; BAC30228.1; -; mRNA.
DR EMBL; BC043031; AAH43031.1; -; mRNA.
DR EMBL; BC058361; AAH58361.1; -; mRNA.
DR CCDS; CCDS19677.1; -.
DR RefSeq; NP_083808.1; NM_029532.2.
DR RefSeq; XP_006530557.1; XM_006530494.3.
DR RefSeq; XP_006530558.1; XM_006530495.3.
DR AlphaFoldDB; Q9D384; -.
DR SMR; Q9D384; -.
DR BioGRID; 218001; 4.
DR STRING; 10090.ENSMUSP00000031349; -.
DR PhosphoSitePlus; Q9D384; -.
DR EPD; Q9D384; -.
DR MaxQB; Q9D384; -.
DR PaxDb; Q9D384; -.
DR PeptideAtlas; Q9D384; -.
DR PRIDE; Q9D384; -.
DR ProteomicsDB; 298248; -.
DR Antibodypedia; 31812; 51 antibodies from 17 providers.
DR DNASU; 76167; -.
DR Ensembl; ENSMUST00000031349; ENSMUSP00000031349; ENSMUSG00000029402.
DR Ensembl; ENSMUST00000111453; ENSMUSP00000107080; ENSMUSG00000029402.
DR GeneID; 76167; -.
DR KEGG; mmu:76167; -.
DR UCSC; uc008zpy.1; mouse.
DR CTD; 11066; -.
DR MGI; MGI:1923417; Snrnp35.
DR VEuPathDB; HostDB:ENSMUSG00000029402; -.
DR eggNOG; KOG0113; Eukaryota.
DR GeneTree; ENSGT00940000157648; -.
DR HOGENOM; CLU_035088_1_0_1; -.
DR InParanoid; Q9D384; -.
DR OMA; FEHERDF; -.
DR OrthoDB; 1430110at2759; -.
DR PhylomeDB; Q9D384; -.
DR TreeFam; TF331614; -.
DR Reactome; R-MMU-72165; mRNA Splicing - Minor Pathway.
DR BioGRID-ORCS; 76167; 24 hits in 73 CRISPR screens.
DR ChiTaRS; Snrnp35; mouse.
DR PRO; PR:Q9D384; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9D384; protein.
DR Bgee; ENSMUSG00000029402; Expressed in embryonic brain and 220 other tissues.
DR ExpressionAtlas; Q9D384; baseline and differential.
DR Genevisible; Q9D384; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:MGI.
DR GO; GO:0005689; C:U12-type spliceosomal complex; ISS:HGNC-UCL.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0017069; F:snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12237; RRM_snRNP35; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034146; snRNP35_RRM.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Isopeptide bond; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; RNA-binding; Spliceosome; Ubl conjugation.
FT CHAIN 1..244
FT /note="U11/U12 small nuclear ribonucleoprotein 35 kDa
FT protein"
FT /id="PRO_0000307908"
FT DOMAIN 51..129
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 146..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..244
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 172
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q16560"
SQ SEQUENCE 244 AA; 29290 MW; 1625D74743CE1245 CRC64;
MSDWMPIAKE YDPLKAGSID GTDEDPHDRA VWRAMLARYV PNKGVTGDPL LTLFVARLNL
QTKEEKLKEV FSRYGDIRRL RLVRDLVTGF SKGYAFIEYK EERALMKAYR DADGLVIDQH
EIFVDYELER TLRGWIPRRL GGGLGGKKES GQLRFGGRDR PFRKPINLPV VKNEPHREGK
RERRERSRSR DRHWDPRPRE RDHDRGREKH WQERARVWPE NDWEREREFR EERVKSRDKR
DRSK
