ID   U20_HHV6U               Reviewed;         422 AA.
AC   Q69555; Q69044;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 71.
DE   RecName: Full=Glycoprotein U20;
DE   Flags: Precursor;
GN   Name=U20; Synonyms=EJLF3;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA   Nicholas J., Martin M.E.D.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT   of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT   homologs and transactivating functions.";
RL   J. Virol. 68:597-610(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16727.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L25528; AAA16727.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X83413; CAA58400.1; -; Genomic_DNA.
DR   PIR; T09314; T09314.
DR   RefSeq; NP_042913.1; NC_001664.2.
DR   PRIDE; Q69555; -.
DR   DNASU; 1487956; -.
DR   GeneID; 1487956; -.
DR   KEGG; vg:1487956; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..422
FT                   /note="Glycoprotein U20"
FT                   /id="PRO_0000342576"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        78
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        119
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        133
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        154
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        227
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        266
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        407
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   422 AA;  48688 MW;  AD90E1C03F61EE67 CRC64;
     MITVFVACLF QCVSSLPAKL YIKTTLAERI GKLQTVIGID NDIVFAYERL YEDLTLLNHT
     VVGETLFDLT GSLEEGKNST VDRFLGHVVI REFHRLHAGL QYVSLRNFSV SELVCFVNNN
     TQLSGSYVFL AGNTTYVQID LFNENRGFVH DLINLSSFLQ NRSLHVLSFY ARRFCVEDIL
     NFYGKVVFGD SRHRPPQVFS KRDTGLLVCT ARRYRPIGTN IQWSIQNQTV SDDHMTDDFI
     RTEIAGQLLY SYERALSRAL SMTQRNFSCE ITHKLLVTPA LLTREDAFSF KGFVNPVKQS
     EDMFPRHNFP APHRKKFNKL QLLWIFTVIP IAAGCMFVYM LTRYILFFVS GGCSLNPNRV
     LKRRRRNDEV PMVIMEVEYC NYEADDYMEL HSVQKVRDNS IAVVCGNNSF DIERQSKISR
     NF