ID   U24_HHV6Z               Reviewed;          88 AA.
AC   Q9QJ42;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   23-FEB-2022, entry version 40.
DE   RecName: Full=U24 protein;
GN   Name=U24;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
RN   [2]
RP   FUNCTION, AND MUTAGENESIS OF 7-PRO--PRO-9.
RX   PubMed=19923186; DOI=10.1128/jvi.01775-09;
RA   Sullivan B.M., Coscoy L.;
RT   "The U24 protein from human herpesvirus 6 and 7 affects endocytic
RT   recycling.";
RL   J. Virol. 84:1265-1275(2010).
CC   -!- FUNCTION: Down-regulates the TCR/CD3E complex and the transferrin
CC       receptor TFRC in host T-cells by blocking them from recycling back to
CC       the cell surface. {ECO:0000269|PubMed:19923186}.
CC   -!- SUBUNIT: Interacts with host ITCH; this interaction probably mediates
CC       ITCH degradation (By similarity). Interacts probably with NEDD4 (By
CC       similarity). {ECO:0000250|UniProtKB:Q69559}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q69559}; Single-
CC       pass membrane protein {ECO:0000305}.
CC   -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC       essential for viral particle budding. They recruit proteins of the host
CC       ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC       ESCRT-associated proteins. Contains one L domain: a PPXY motif which is
CC       involved in the interaction with Itch, a member of the Nedd4 family.
CC       {ECO:0000250|UniProtKB:Q69559}.
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DR   EMBL; AF157706; AAD49637.1; -; Genomic_DNA.
DR   RefSeq; NP_050204.1; NC_000898.1.
DR   PRIDE; Q9QJ42; -.
DR   DNASU; 1497025; -.
DR   GeneID; 1497025; -.
DR   KEGG; vg:1497025; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..88
FT                   /note="U24 protein"
FT                   /id="PRO_0000408427"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           8..11
FT                   /note="PPXY motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q69559"
FT   MOD_RES         6
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q69559"
FT   MUTAGEN         7..9
FT                   /note="PPP->AAA: Complete loss of the ability to down-
FT                   regulate the TCR complex."
FT                   /evidence="ECO:0000269|PubMed:19923186"
SQ   SEQUENCE   88 AA;  10152 MW;  49481C2765FA6FF2 CRC64;
     MDRPRTPPPS YSEVLMMDVM YGQVSPHASN DTSFVECLPP PQSSRSAWNL WNKRRKTFAF
     LVLTGLAIAM ILFIAFVIYV FNVNRRKK