ID   U24_HHV7J               Reviewed;          82 AA.
AC   Q69505;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 63.
DE   RecName: Full=U24 protein;
GN   Name=U24 {ECO:0000312|EMBL:AAC54685.1};
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7745696; DOI=10.1128/jvi.69.6.3490-3500.1995;
RA   Pfeiffer B., Thomson B., Chandran B.;
RT   "Identification and characterization of a cDNA derived from multiple
RT   splicing that encodes envelope glycoprotein gp105 of human herpesvirus 6.";
RL   J. Virol. 69:3490-3500(1995).
RN   [2]
RP   FUNCTION, AND MUTAGENESIS OF 6-PRO--PRO-8.
RC   STRAIN=RK;
RX   PubMed=19923186; DOI=10.1128/jvi.01775-09;
RA   Sullivan B.M., Coscoy L.;
RT   "The U24 protein from human herpesvirus 6 and 7 affects endocytic
RT   recycling.";
RL   J. Virol. 84:1265-1275(2010).
RN   [3]
RP   INTERACTION WITH NEDD4 WW DOMAINS.
RX   PubMed=28051106; DOI=10.1038/srep39776;
RA   Sang Y., Zhang R., Scott W.R., Creagh A.L., Haynes C.A., Straus S.K.;
RT   "U24 from Roseolovirus interacts strongly with Nedd4 WW Domains.";
RL   Sci. Rep. 7:39776-39776(2017).
CC   -!- FUNCTION: Down-regulates of the TCR/CD3E complex and the transferrin
CC       receptor TFRC in host T-cells by blocking them from recycling back to
CC       the cell surface. {ECO:0000269|PubMed:19923186}.
CC   -!- SUBUNIT: Interacts with host ITCH; this interaction probably mediates
CC       ITCH degradation (By similarity). Interacts probably with NEDD4
CC       (PubMed:28051106). {ECO:0000250|UniProtKB:Q69559,
CC       ECO:0000269|PubMed:28051106}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q69559}; Single-
CC       pass membrane protein {ECO:0000305}.
CC   -!- DOMAIN: Late-budding domains (L domains) are short sequence motifs
CC       essential for viral particle budding. They recruit proteins of the host
CC       ESCRT machinery (Endosomal Sorting Complex Required for Transport) or
CC       ESCRT-associated proteins. Contains one L domain: a PPXY motif which is
CC       involved in the interaction with Itch, a member of the Nedd4 family.
CC       {ECO:0000250|UniProtKB:Q69559}.
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DR   EMBL; U43400; AAC54685.1; -; Genomic_DNA.
DR   PIR; T41925; T41925.
DR   RefSeq; YP_073763.1; NC_001716.2.
DR   SMR; Q69505; -.
DR   DNASU; 3289481; -.
DR   GeneID; 3289481; -.
DR   KEGG; vg:3289481; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..82
FT                   /note="U24 protein"
FT                   /id="PRO_0000448381"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           7..10
FT                   /note="PPXY motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q69559"
FT   MUTAGEN         6..8
FT                   /note="PPP->AAA: Complete loss of the ability to down-
FT                   regulate the TCR complex."
FT                   /evidence="ECO:0000269|PubMed:19923186"
SQ   SEQUENCE   82 AA;  9377 MW;  A25E73FE6C3977AD CRC64;
     MTHETPPPSY NDVMLQMFHD HSVFLHQENL SPRTINSTSS SEIKNVRRRG TFIILACLII
     SVILCLILIL HIFNVRYGGT KP