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U31H_SCYTH
ID   U31H_SCYTH              Reviewed;          71 AA.
AC   A0A0A0VBR5;
DT   11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT   04-FEB-2015, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=U3-scytotoxin-Sth1h {ECO:0000303|PubMed:24303891, ECO:0000303|PubMed:27227898};
DE            Short=U3-SYTX-Sth1h {ECO:0000303|PubMed:24303891};
DE            Short=U3-Sth1h {ECO:0000303|PubMed:27227898};
DE   Flags: Precursor;
OS   Scytodes thoracica (Spitting spider) (Aranea thoracica).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Haplogynae; Scytodoidea; Scytodidae; Scytodes.
OX   NCBI_TaxID=1112478;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=24303891; DOI=10.1021/pr400875s;
RA   Zobel-Thropp P.A., Correa S.M., Garb J.E., Binford G.J.;
RT   "Spit and venom from scytodes spiders: a diverse and distinct cocktail.";
RL   J. Proteome Res. 13:817-835(2014).
RN   [2] {ECO:0007744|PDB:5FZW}
RP   STRUCTURE BY NMR OF 40-71, FUNCTION, AND DISULFIDE BONDS.
RX   PubMed=27227898; DOI=10.1371/journal.pone.0156291;
RA   Ariki N.K., Munoz L.E., Armitage E.L., Goodstein F.R., George K.G.,
RA   Smith V.L., Vetter I., Herzig V., King G.F., Loening N.M.;
RT   "Characterization of three venom peptides from the spitting spider Scytodes
RT   thoracica.";
RL   PLoS ONE 11:E0156291-E0156291(2016).
CC   -!- FUNCTION: Probable insect neurotoxin with ion channel impairing
CC       activity (Probable). Does not show activity on 45 human receptors from
CC       9 families (5-hydroxytryptamine, adrenergic, dopamine, muscarinic,
CC       histamine, neurotransmitter, opioid, sigma, and gaba(A) receptors)
CC       (PubMed:27227898). In vivo, when mixed with U3-SYTX-Sth1a does not
CC       cause paralytic or lethal activity when injected into crickets
CC       (PubMed:27227898). It is noteworthy that crickets are evolutionarily
CC       distant from prey species (PubMed:27227898).
CC       {ECO:0000269|PubMed:27227898}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24303891}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24303891}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000269|PubMed:27227898}.
CC   -!- WEB RESOURCE: Name=Biological Magnetic Resonance Data Bank;
CC       URL="http://www.bmrb.wisc.edu/data_library/summary/index.php?bmrbId=26003";
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DR   EMBL; KF860358; AIW62383.1; -; mRNA.
DR   PDB; 5FZW; NMR; -; A=40-71.
DR   PDBsum; 5FZW; -.
DR   AlphaFoldDB; A0A0A0VBR5; -.
DR   SMR; A0A0A0VBR5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Ion channel impairing toxin; Knottin;
KW   Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   PROPEP          34..39
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000448640"
FT   CHAIN           40..71
FT                   /note="U3-scytotoxin-Sth1h"
FT                   /id="PRO_5001970751"
FT   DISULFID        46..60
FT                   /evidence="ECO:0000269|PubMed:27227898,
FT                   ECO:0007744|PDB:5FZW"
FT   DISULFID        53..64
FT                   /evidence="ECO:0000269|PubMed:27227898,
FT                   ECO:0007744|PDB:5FZW"
FT   DISULFID        59..69
FT                   /evidence="ECO:0000269|PubMed:27227898,
FT                   ECO:0007744|PDB:5FZW"
FT   STRAND          41..43
FT                   /evidence="ECO:0007829|PDB:5FZW"
FT   HELIX           56..58
FT                   /evidence="ECO:0007829|PDB:5FZW"
SQ   SEQUENCE   71 AA;  7934 MW;  A0E3F197E173838E CRC64;
     MSQNSITSYK MGFAKHFFLF AVLLCATAMY SVAEPAQERL IESIACMQKG LPCMEHVDCC
     HGVCDSLFCL Y
 
 
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