ID   U375E_CAEEL             Reviewed;         117 AA.
AC   O45941;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=UPF0375 protein Y45F10C.2;
DE   Flags: Precursor;
GN   ORFNames=Y45F10C.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, TISSUE SPECIFICITY, AND MUTAGENESIS OF CYS-36.
RX   PubMed=21573134; DOI=10.1371/journal.pgen.1002065;
RA   Hao Y., Xu N., Box A.C., Schaefer L., Kannan K., Zhang Y., Florens L.,
RA   Seidel C., Washburn M.P., Wiegraebe W., Mak H.Y.;
RT   "Nuclear cGMP-dependent kinase regulates gene expression via activity-
RT   dependent recruitment of a conserved histone deacetylase complex.";
RL   PLoS Genet. 7:E1002065-E1002065(2011).
CC   -!- FUNCTION: Negatively regulates the egg-laying rate by promoting
CC       retention of fertilized eggs. {ECO:0000269|PubMed:21573134}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the uterine epithelium.
CC       {ECO:0000269|PubMed:21573134}.
CC   -!- SIMILARITY: Belongs to the UPF0375 family. {ECO:0000305}.
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DR   EMBL; Z99273; CAB16475.1; -; Genomic_DNA.
DR   PIR; T26924; T26924.
DR   RefSeq; NP_502639.1; NM_070238.6.
DR   AlphaFoldDB; O45941; -.
DR   STRING; 6239.Y45F10C.2; -.
DR   EPD; O45941; -.
DR   PaxDb; O45941; -.
DR   PeptideAtlas; O45941; -.
DR   EnsemblMetazoa; Y45F10C.2.1; Y45F10C.2.1; WBGene00012878.
DR   GeneID; 178334; -.
DR   KEGG; cel:CELE_Y45F10C.2; -.
DR   UCSC; Y45F10C.2; c. elegans.
DR   CTD; 178334; -.
DR   WormBase; Y45F10C.2; CE16636; WBGene00012878; -.
DR   GeneTree; ENSGT00390000003521; -.
DR   HOGENOM; CLU_2086981_0_0_1; -.
DR   PhylomeDB; O45941; -.
DR   PRO; PR:O45941; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00012878; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009981; DUF1505.
DR   Pfam; PF07403; DUF1505; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..117
FT                   /note="UPF0375 protein Y45F10C.2"
FT                   /id="PRO_0000248527"
FT   MUTAGEN         36
FT                   /note="C->A: Promotes egg-laying."
FT                   /evidence="ECO:0000269|PubMed:21573134"
SQ   SEQUENCE   117 AA;  12842 MW;  DE4E349D8B194F74 CRC64;
     MNSFVSTVLL LSVTIALVSG YPSQLQTTCV TKAKSCTMFF LNGVYCTECT YSGTLELKIG
     STCTFSIYEK KVASQPNENS QNEVAQCKQS SCYSNQYVPV DCAAAFGNEY ITYIENQ