ID   U376D_CAEEL             Reviewed;         219 AA.
AC   O16406;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=UPF0376 protein C36C5.12;
GN   ORFNames=C36C5.12;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-104, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   STRAIN=Bristol N2;
RX   PubMed=12754521; DOI=10.1038/nbt829;
RA   Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA   Kasai K., Takahashi N., Isobe T.;
RT   "Lectin affinity capture, isotope-coded tagging and mass spectrometry to
RT   identify N-linked glycoproteins.";
RL   Nat. Biotechnol. 21:667-672(2003).
RN   [3]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-104, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   STRAIN=Bristol N2;
RX   PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA   Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA   Taoka M., Takahashi N., Isobe T.;
RT   "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT   elegans and suggests an atypical translocation mechanism for integral
RT   membrane proteins.";
RL   Mol. Cell. Proteomics 6:2100-2109(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0376 family. {ECO:0000305}.
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DR   EMBL; FO080796; CCD66864.1; -; Genomic_DNA.
DR   PIR; D88990; D88990.
DR   RefSeq; NP_503869.2; NM_071468.2.
DR   AlphaFoldDB; O16406; -.
DR   BioGRID; 48098; 1.
DR   STRING; 6239.C36C5.12; -.
DR   iPTMnet; O16406; -.
DR   PaxDb; O16406; -.
DR   PeptideAtlas; O16406; -.
DR   EnsemblMetazoa; C36C5.12.1; C36C5.12.1; WBGene00016481.
DR   EnsemblMetazoa; C36C5.12.2; C36C5.12.2; WBGene00016481.
DR   GeneID; 183268; -.
DR   KEGG; cel:CELE_C36C5.12; -.
DR   UCSC; C36C5.12; c. elegans.
DR   CTD; 183268; -.
DR   WormBase; C36C5.12; CE51178; WBGene00016481; -.
DR   eggNOG; ENOG502THJ5; Eukaryota.
DR   GeneTree; ENSGT00970000195826; -.
DR   HOGENOM; CLU_078890_1_0_1; -.
DR   InParanoid; O16406; -.
DR   OMA; KEDEHRN; -.
DR   PhylomeDB; O16406; -.
DR   PRO; PR:O16406; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00016481; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR002542; DUF19.
DR   InterPro; IPR016638; UPF0376.
DR   Pfam; PF01579; DUF19; 1.
DR   PIRSF; PIRSF015697; UCP015697; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..219
FT                   /note="UPF0376 protein C36C5.12"
FT                   /id="PRO_0000248558"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..43
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..219
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:12754521,
FT                   ECO:0000269|PubMed:17761667"
FT   CARBOHYD        204
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  25309 MW;  0B7488D3F392475C CRC64;
     MGRLDVKNSW IEFHQDEMTS FLKLAIIGTV LLGVAHGANL TAAEKETYCE LRSAIQTFLC
     IERLRDFAAK VDELDMDKKS ELKEFKKTCD SLKNCFAITR CGPNSTMDEA ELFRMVEKNC
     EAVVYIHEDF SDCSDKLTAK KSVCFDNWDP IPDGIHLEED EKKVEKMKKE TCKRYFGKDD
     CMKKEIVETC SQKEWDKFRE QFINLSSDLV SKCDFSRLG