U496K_ARATH
ID U496K_ARATH Reviewed; 390 AA.
AC Q6DYE5; Q5BQ01; Q9LNU2;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=UPF0496 protein At1g20180;
GN OrderedLocusNames=At1g20180; ORFNames=T20H2.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Xiao Y.-L., Underwood B.A., Moskal W.A. Jr., Torian U., Redman J.C.,
RA Wu H.C., Utterback T., Town C.D.;
RT "Reconstruction of cDNA sequences for hypothetical genes in Arabidopsis
RT thaliana from 5' and 3' RACE products.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6DYE5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6DYE5-2; Sequence=VSP_028564;
CC -!- SIMILARITY: Belongs to the UPF0496 family. {ECO:0000305}.
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DR EMBL; AC022472; AAF79896.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29947.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29948.1; -; Genomic_DNA.
DR EMBL; DQ446265; ABE65635.1; -; mRNA.
DR EMBL; AY630760; AAT67559.1; -; mRNA.
DR EMBL; AY924677; AAX23752.1; -; mRNA.
DR PIR; E86335; E86335.
DR RefSeq; NP_001077567.1; NM_001084098.1. [Q6DYE5-2]
DR RefSeq; NP_173445.2; NM_101871.3. [Q6DYE5-1]
DR AlphaFoldDB; Q6DYE5; -.
DR SMR; Q6DYE5; -.
DR PaxDb; Q6DYE5; -.
DR PRIDE; Q6DYE5; -.
DR EnsemblPlants; AT1G20180.1; AT1G20180.1; AT1G20180. [Q6DYE5-1]
DR EnsemblPlants; AT1G20180.2; AT1G20180.2; AT1G20180. [Q6DYE5-2]
DR GeneID; 838607; -.
DR Gramene; AT1G20180.1; AT1G20180.1; AT1G20180. [Q6DYE5-1]
DR Gramene; AT1G20180.2; AT1G20180.2; AT1G20180. [Q6DYE5-2]
DR KEGG; ath:AT1G20180; -.
DR Araport; AT1G20180; -.
DR TAIR; locus:2198591; AT1G20180.
DR eggNOG; ENOG502QVA7; Eukaryota.
DR InParanoid; Q6DYE5; -.
DR OMA; SSRHYAR; -.
DR PhylomeDB; Q6DYE5; -.
DR PRO; PR:Q6DYE5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6DYE5; baseline and differential.
DR Genevisible; Q6DYE5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007749; DUF677.
DR PANTHER; PTHR31113; PTHR31113; 1.
DR Pfam; PF05055; DUF677; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..390
FT /note="UPF0496 protein At1g20180"
FT /id="PRO_0000306896"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 220..250
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.5"
FT /id="VSP_028564"
FT CONFLICT 20
FT /note="G -> E (in Ref. 5; AAX23752)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="M -> T (in Ref. 4; AAT67559)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 390 AA; 44074 MW; 4C7EC3B286886928 CRC64;
MLKVKNFLGS RLKSFPTRKG KSDKECCRSL TSKLSVNEEY KEAFRTNSYL ETRTKAEDQL
GITSCSKLSS SSPSPSSSSD LSFHSHFTDY LLDPPQETLD ALMQDSSLDN LIVTFFDLSS
EACDVCETLL QCLQQIKINH NKIKRVMKIG KRVCNGAKTL ECSPEMLCAL IFQELSRFAA
LKNPLCRIVN EAQFRIVHDA NSDLLTKLTS KKRRIRRKIR FFKFCKKLGG YSLVITHSAI
VITLLIIALH SILGVFAAPA LLGLCSFCLL RKKKAKGRMH KSNKDTTLEK LGTQIDIAAK
GMFILINDLD TLSRLAGRLC DEIEHRKTVA AMCAKSRKIE VLKEALREFN GHEEKFSDQL
QELEEHLYLC FHTINRSRRL VLAQITGQSS
