ID   U499_ASPCL              Reviewed;          71 AA.
AC   A1CTH7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=UPF0499 protein ACLA_083080;
DE   Flags: Precursor;
GN   ORFNames=ACLA_083080;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0499 family. {ECO:0000305}.
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DR   EMBL; DS027060; EAW06614.1; -; Genomic_DNA.
DR   RefSeq; XP_001268040.1; XM_001268039.1.
DR   AlphaFoldDB; A1CTH7; -.
DR   EnsemblFungi; EAW06614; EAW06614; ACLA_083080.
DR   GeneID; 4699769; -.
DR   KEGG; act:ACLA_083080; -.
DR   VEuPathDB; FungiDB:ACLA_083080; -.
DR   eggNOG; ENOG502RPNC; Eukaryota.
DR   HOGENOM; CLU_2739561_0_0_1; -.
DR   OMA; CDMRSLT; -.
DR   OrthoDB; 1644987at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..71
FT                   /note="UPF0499 protein ACLA_083080"
FT                   /id="PRO_0000307900"
FT   DISULFID        44..58
FT                   /evidence="ECO:0000305"
FT   DISULFID        48..61
FT                   /evidence="ECO:0000305"
FT   DISULFID        54..68
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   71 AA;  7369 MW;  9E8B23CA508C22BD CRC64;
     MKFLNILTLA FITGMASAAA VPGGTTTNDA ASTLDNLNNK RSVCGQLCFN NKDCGGPCPK
     CNTKEGVCVK K