ID   U499_CHAGB              Reviewed;          73 AA.
AC   Q2H5P4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=UPF0499 protein CHGG_06021;
DE   Flags: Precursor;
GN   ORFNames=CHGG_06021;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0499 family. {ECO:0000305}.
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DR   EMBL; CH408031; EAQ89402.1; -; Genomic_DNA.
DR   RefSeq; XP_001222116.1; XM_001222115.1.
DR   AlphaFoldDB; Q2H5P4; -.
DR   EnsemblFungi; EAQ89402; EAQ89402; CHGG_06021.
DR   GeneID; 4390461; -.
DR   eggNOG; ENOG502RJ86; Eukaryota.
DR   HOGENOM; CLU_185484_0_0_1; -.
DR   InParanoid; Q2H5P4; -.
DR   OMA; CCAGLKC; -.
DR   OrthoDB; 1645082at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..73
FT                   /note="UPF0499 protein CHGG_06021"
FT                   /id="PRO_0000307902"
FT   DISULFID        41..55
FT                   /evidence="ECO:0000305"
FT   DISULFID        48..60
FT                   /evidence="ECO:0000305"
FT   DISULFID        54..69
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   73 AA;  7761 MW;  638937C50E308C70 CRC64;
     MKSSIHVVLF FLLSLVASMA LPRRQAQAPF AVVDFSGKAA CHSILTSCRV DTDCCAGLKC
     GIFDEDALCV PQG