ID   U499_NEOFI              Reviewed;          73 AA.
AC   A1DMY0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=UPF0499 protein NFIA_054990;
DE   Flags: Precursor;
GN   ORFNames=NFIA_054990;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0499 family. {ECO:0000305}.
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DR   EMBL; DS027698; EAW16151.1; -; Genomic_DNA.
DR   RefSeq; XP_001258048.1; XM_001258047.1.
DR   AlphaFoldDB; A1DMY0; -.
DR   SMR; A1DMY0; -.
DR   EnsemblFungi; EAW16151; EAW16151; NFIA_054990.
DR   GeneID; 4584563; -.
DR   KEGG; nfi:NFIA_054990; -.
DR   VEuPathDB; FungiDB:NFIA_054990; -.
DR   eggNOG; ENOG502RPNC; Eukaryota.
DR   HOGENOM; CLU_2739561_0_0_1; -.
DR   OMA; CDMRSLT; -.
DR   OrthoDB; 1631475at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..73
FT                   /note="UPF0499 protein NFIA_054990"
FT                   /id="PRO_0000307903"
FT   DISULFID        46..60
FT                   /evidence="ECO:0000305"
FT   DISULFID        50..63
FT                   /evidence="ECO:0000305"
FT   DISULFID        56..70
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   73 AA;  7639 MW;  445B7E65D0488006 CRC64;
     MKSFNLLSLS LLLAIASAAA VPDVEGTITN DAATPVNNLD DKRDHCGQVC LNKTGCGGKC
     PKCDMRSLTC KKA