ID   U499_NEUCR              Reviewed;          84 AA.
AC   Q7S163;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=UPF0499 protein NCU07353;
DE   Flags: Precursor;
GN   ORFNames=NCU07353;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0499 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM002236; EAA29097.1; -; Genomic_DNA.
DR   RefSeq; XP_958333.1; XM_953240.2.
DR   AlphaFoldDB; Q7S163; -.
DR   SMR; Q7S163; -.
DR   PRIDE; Q7S163; -.
DR   EnsemblFungi; EAA29097; EAA29097; NCU07353.
DR   GeneID; 3874480; -.
DR   KEGG; ncr:NCU07353; -.
DR   VEuPathDB; FungiDB:NCU07353; -.
DR   HOGENOM; CLU_185484_0_0_1; -.
DR   InParanoid; Q7S163; -.
DR   OMA; DYRYAPQ; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..84
FT                   /note="UPF0499 protein NCU07353"
FT                   /id="PRO_0000307904"
FT   DISULFID        52..66
FT                   /evidence="ECO:0000305"
FT   DISULFID        59..71
FT                   /evidence="ECO:0000305"
FT   DISULFID        65..80
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   84 AA;  8980 MW;  3ACA7515892CEB81 CRC64;
     MKASIVLVSF LGLVSGMVLP GHRLSPSGAK LQPRSLFKRE ANLDYRYAPE PCRAILTTCR
     VTSDCCSGMK CVSADGESVC TPSD