ID   U5072_YEAST             Reviewed;         737 AA.
AC   P0CF17; D6VZH3; Q03665; Q04257; Q04263; Q6B2L5; Q6WV03;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=UPF0507 protein YML002W;
GN   OrderedLocusNames=YML002W; ORFNames=YM8270.01, YM9571.17;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
CC   -!- SIMILARITY: Belongs to the UPF0507 family. {ECO:0000305}.
CC   -!- CAUTION: This is a truncated version of an UPF0507 family protein.
CC       Strain S288c has a frameshift in position 286, which disrupts the gene
CC       coding for this protein and produces two ORFs YML003W and YML002W. A
CC       contiguous sequence for a S.cerevisiae UPF0507 family protein can be
CC       found in strain YJM789 (AC A6ZM60). {ECO:0000305}.
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DR   EMBL; Z49810; CAA89950.1; -; Genomic_DNA.
DR   EMBL; Z48613; CAA88514.1; -; Genomic_DNA.
DR   EMBL; AY692715; AAT92734.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA09897.1; -; Genomic_DNA.
DR   PIR; S55117; S55117.
DR   RefSeq; NP_013712.1; NM_001182357.1.
DR   AlphaFoldDB; P0CF17; -.
DR   SMR; P0CF17; -.
DR   BioGRID; 35169; 46.
DR   STRING; 4932.YML002W; -.
DR   PaxDb; P0CF17; -.
DR   PRIDE; P0CF17; -.
DR   EnsemblFungi; YML002W_mRNA; YML002W; YML002W.
DR   GeneID; 855011; -.
DR   KEGG; sce:YML002W; -.
DR   SGD; S000004461; YML002W.
DR   VEuPathDB; FungiDB:YML002W; -.
DR   eggNOG; ENOG502R3ZQ; Eukaryota.
DR   GeneTree; ENSGT00940000176527; -.
DR   HOGENOM; CLU_008912_0_0_1; -.
DR   InParanoid; P0CF17; -.
DR   OMA; EYVELNL; -.
DR   BioCyc; YEAST:G3O-32608-MON; -.
DR   PRO; PR:P0CF17; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; P0CF17; protein.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030133; C:transport vesicle; IBA:GO_Central.
DR   GO; GO:0097422; C:tubular endosome; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0045022; P:early endosome to late endosome transport; IBA:GO_Central.
DR   Gene3D; 1.20.1050.80; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR003123; VPS9.
DR   InterPro; IPR037191; VPS9_dom_sf.
DR   Pfam; PF02204; VPS9; 1.
DR   SUPFAM; SSF109993; SSF109993; 1.
DR   PROSITE; PS51205; VPS9; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..737
FT                   /note="UPF0507 protein YML002W"
FT                   /id="PRO_0000393363"
FT   DOMAIN          1..83
FT                   /note="VPS9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00550"
FT   CONFLICT        32
FT                   /note="R -> S (in Ref. 3; AAT92734)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   737 AA;  84602 MW;  5623E6E6A073657C CRC64;
     MDSHQLELPD GLNNMTMDAD TLISLFVLVV CRSEQKHLKS HLYYLQNFSN NSSSTKFGIL
     GYAVSTLEAV VCYFEDFNKN TGNVAKANTL CEKTKNLLDK LSCENPTNEV EDLATYKDIL
     TYRNEQGQSI LSICITNHKN YILLDILSEY ENDFPVEDLL EDETIDGSTL LIESIKAGNL
     EAAKVLIKIM LFNCTEEELV SYINKTDKYA RTVAHYLTHE MDILKSIGNY IDWKRKNSSG
     QTPLFSIFRS YDQPNYEEMV KTAFDIANTW YRKHNSLFDY LDHTDNKGNS LLHVLKTNIP
     ILLQLTKLDI NEENYKGLTP LMVYVKYKRL SNIDAITKDR RLILEKVQNS TFFTCFDYAK
     DHSVLSKIGE RGVKDSLFGL IYFHSLRYHN LNATTNITSV SNAEKPFATT VINMKTIQGL
     LRSILKDNPF TFLPLNTYID EISHLNRSDL TIIGKTDVTS LLHQLTNCFN VLLFLKKIPE
     NLFTDEASIL YWMRINTSKR NQKPSGKENP KTMEPEEINM IQSFLRFNFD EISSFKASLN
     ILRKVLIFIN LKSDDFEDAY KGLNEMGRKL INSEASSAFK GIITNHNMFS ELSLAALLEN
     VRFLEQCTIQ LSSFVQIILF EKIPNWWKHY GEFLALHKSY RKAFPNMVKP KSASDTSSRA
     PLGGFIETKR EQSEQRLAVQ IKASSKMLKE LGSEIFVAHE RLAEELSNYM EFRKACLDQR
     SLVAFATTNI SVLQECV