ID   U518_AEDAE              Reviewed;        1042 AA.
AC   Q17AI4;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=FHIP family protein AAEL005291;
GN   ORFNames=AAEL005291;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- SIMILARITY: Belongs to the FHIP family. {ECO:0000305}.
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DR   EMBL; CH477335; EAT43238.1; -; Genomic_DNA.
DR   RefSeq; XP_001650683.1; XM_001650633.1.
DR   AlphaFoldDB; Q17AI4; -.
DR   STRING; 7159.AAEL005291-PA; -.
DR   GeneID; 5566304; -.
DR   KEGG; aag:5566304; -.
DR   VEuPathDB; VectorBase:AAEL022240; -.
DR   eggNOG; KOG3695; Eukaryota.
DR   HOGENOM; CLU_007807_0_0_1; -.
DR   InParanoid; Q17AI4; -.
DR   OMA; CLDWDSG; -.
DR   PhylomeDB; Q17AI4; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   InterPro; IPR019384; FHIP.
DR   InterPro; IPR045669; FHIP_C.
DR   InterPro; IPR045668; FHIP_KELAA_motif.
DR   PANTHER; PTHR21705; PTHR21705; 1.
DR   Pfam; PF19314; DUF5917; 1.
DR   Pfam; PF19311; KELAA; 1.
DR   Pfam; PF10257; RAI16-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..1042
FT                   /note="FHIP family protein AAEL005291"
FT                   /id="PRO_0000379004"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          494..514
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          821..866
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          905..977
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        835..861
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        905..941
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        962..977
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1042 AA;  114531 MW;  4F21370F9551B18C CRC64;
     MSWLRSSPLR QSFSKAGGGS GSGASSRGGN STNGTVRAFD ASECDPKACY DSFCIHWQQA
     FEIIQRSENN RGQSHDDVLG VVTHLDHMVT LLLVELHHCN KVGLPGAPAP PAPCLEHLLS
     ENLLDKLYEW GVKTGRYANA VRLEQLKLYE QLVSHSRHQL LVHEPFLRPL LKILASSQNE
     IYPPDVEKRL VILLNQLCVV LMQNVHLLDL FFFSTAQQNG SGGHANFIIF SLLIPYVHQE
     GSLGHQARDA LLLCMACPRR LDRGTYIATY SSICPVWFTR AGEGLYSRLP NQIDIKTIDW
     YRITTDDVTE LQELTLFMNS LEFCNAVVQV AHSMIRQQLL DFLYQGFLVP VLGPAVLQTN
     VESQISAMAY LDLIVRSVTE PGLIQIVVKF LLDEEKFDGQ RILDVLVERL NSNDTRLCMV
     SLSLFDTLLS LNCEDIMLEL ALKYLLNCQH VPISHRFKVN RVDPYSNAVE YFLNTSPDIM
     KKVNNVLNIN NNNNNTSQAS SMLGSGPSSM PQGGRNVSKT IGANWNHYGN NTGETLMANY
     QAYLLEARNR IVQCKHACDQ WNNVYRYQKL SKLVNNSSSL SHSGNGTAGS EDVRTYKVQM
     IKNFLAEFTT APDSAVDMAG DGDRSSLCQS PAGMFGTGHH ASHLMATTSK QLDSLQSLGD
     SSGYESLNIT NLGTGSEDGR RHEAWKVSSV KEETIVDLDL SEDLFAQGTV SLGPFLTAIW
     GKLQTFTSNC LYVNLHLTGL ISHLAWFPLP LLHSILLRPD IPTTSDTPSF HQVLKILKQQ
     IDAELPDCDE SLEIVDVARS FLVDREFRLI NMRKNAIESN PHSGKLLLPN GATGASGPVS
     MTSNLSQTTP MQLTPSSSYD PFKRNDTKRK SISNSFSSIF RRPGSSASSG LAQVFQFFTG
     GGSSSNSSSI SHQSSSTPSP AGSQQYLSSN SSGVSSFMGS SRRESREAET QFVDHPSIGG
     PPSSMGPTSL TSTGSPHNSL EYSLVNINGS IVGGIGSERQ RDLAVSAVVL DEWLKELAAI
     TQEQCIIMIS DQVSSQKPGK LS