U518_DROME
ID U518_DROME Reviewed; 1041 AA.
AC Q9VQK0; B7Z000; Q8IPZ4; Q95SN7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=FHIP family protein CG3558;
GN ORFNames=CG3558;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 517-1041 (ISOFORM B).
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490 AND SER-797, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=A;
CC IsoId=Q9VQK0-1; Sequence=Displayed;
CC Name=C;
CC IsoId=Q9VQK0-3; Sequence=VSP_037630;
CC Name=B;
CC IsoId=Q9VQK0-2; Sequence=VSP_031496;
CC -!- SIMILARITY: Belongs to the FHIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL28233.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF51167.1; -; Genomic_DNA.
DR EMBL; AE014134; AAN10405.1; -; Genomic_DNA.
DR EMBL; AE014134; ACL82984.1; -; Genomic_DNA.
DR EMBL; BT021330; AAX33478.1; -; mRNA.
DR EMBL; AY060685; AAL28233.1; ALT_INIT; mRNA.
DR RefSeq; NP_001137777.1; NM_001144305.2. [Q9VQK0-3]
DR RefSeq; NP_652064.2; NM_143807.3. [Q9VQK0-1]
DR RefSeq; NP_722866.1; NM_164519.2. [Q9VQK0-2]
DR AlphaFoldDB; Q9VQK0; -.
DR BioGRID; 71376; 4.
DR IntAct; Q9VQK0; 2.
DR STRING; 7227.FBpp0271738; -.
DR iPTMnet; Q9VQK0; -.
DR PaxDb; Q9VQK0; -.
DR DNASU; 48421; -.
DR EnsemblMetazoa; FBtr0077644; FBpp0077329; FBgn0025681. [Q9VQK0-1]
DR EnsemblMetazoa; FBtr0077645; FBpp0077330; FBgn0025681. [Q9VQK0-2]
DR EnsemblMetazoa; FBtr0273230; FBpp0271738; FBgn0025681. [Q9VQK0-3]
DR GeneID; 48421; -.
DR KEGG; dme:Dmel_CG3558; -.
DR UCSC; CG3558-RA; d. melanogaster. [Q9VQK0-1]
DR FlyBase; FBgn0025681; CG3558.
DR VEuPathDB; VectorBase:FBgn0025681; -.
DR eggNOG; KOG3695; Eukaryota.
DR GeneTree; ENSGT00950000182936; -.
DR InParanoid; Q9VQK0; -.
DR PhylomeDB; Q9VQK0; -.
DR BioGRID-ORCS; 48421; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 48421; -.
DR PRO; PR:Q9VQK0; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0025681; Expressed in oviduct (Drosophila) and 24 other tissues.
DR ExpressionAtlas; Q9VQK0; baseline and differential.
DR Genevisible; Q9VQK0; DM.
DR InterPro; IPR019384; FHIP.
DR InterPro; IPR045669; FHIP_C.
DR InterPro; IPR045668; FHIP_KELAA_motif.
DR PANTHER; PTHR21705; PTHR21705; 1.
DR Pfam; PF19314; DUF5917; 1.
DR Pfam; PF19311; KELAA; 1.
DR Pfam; PF10257; RAI16-like; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..1041
FT /note="FHIP family protein CG3558"
FT /id="PRO_0000319580"
FT REGION 619..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 903..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 490
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 797
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VAR_SEQ 356
FT /note="L -> LQTLKGKHF (in isoform C)"
FT /evidence="ECO:0000305"
FT /id="VSP_037630"
FT VAR_SEQ 877..889
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_031496"
SQ SEQUENCE 1041 AA; 113845 MW; E6A55D655AA854EC CRC64;
MWLRQSSGGG VASVGHVGPL RQRPIDAATD CDPRACYDSF CKHWQQAFEI IQHSAPPSHD
DVLGVVSHLD YMVTLLLVEL HHCNKVSLPA AEASGPPAAP CLEFLLSENL LDKLYEWACT
TGRYANAVRL EQLKLYELLV SHSRHQLLCH EPFLRPLLKI LASSQGEIFP PDLEKRLVIL
LNQLCVVLMQ NVHLLDLFFF SAQTQVQEQI LNGNVAPPKS GTTTNFIIFS LLIPYVHREG
SLGHQARDAL LLCMALSQKN SNIGTYIAQY SSICPLLVTG LGGLYSRLPN SIEISSIDWH
RITPDDVTEI PELTLFMNAL EFCNAVVQVA HEMIKQQLLD FMYQGFIVPV LGPAILQTNI
DSQISAMSYL DLILRSITEP GLLRAFVRFL LDTEKFDGER ILDALVERLN SPDANLCMVT
MALFDTLLGL HCEDLMLELL LKFMLPGKHV PISHRHKINK IDPYLNSSEF FLELSPDVMK
RARDLARPKS VHEPVVSELT PLPSLPSPVM SKTIGANWNY YGVHTGDSLY ANIQAYLFEA
HWRIAQCQKD CLKWANSYRY QKWPRHGQGR VHAHALELAR QFFSEFGGGP IAANETGEKQ
LDSLQSIGES SGYESFKWRP ADEESEATDT TVATTASEAD MDHNSSSLSS VLGASGKRES
WRTSNSNRNE LILTDLDFSE DLFAQGTVSL GPFLNAIWGK LQTFTSNSLY VNLHLTGLIT
RLAWYPLPLI HSLLLRSDIA ITSDTPSFHQ VLRILKQQID AELPVTEDSL EIIDVARSSL
IDREFRLANA RKGNEGSPMH HSQQQQMVTN SGQQQGQLRS AYATLSAATP VQATPTSAYD
PFKRSDNKRR SISKSITSMF SRKSASTSTA PPNGSSASSG LSQIYAFFTG AASNLVGNNA
SNDGRGISQA QTSAGTCETS LSTQPPAGAS RTGANATSTA ASGSNSSIAG STLTLSAQSN
TTTHSASTLH GLDGGPSTGG FNSEPASLDS VASMGIIAST SGTERSRDLA LCAVLMDEWL
KELAAIAQEQ SVVLVTEQGS L
