ID   U518_DROPS              Reviewed;        1081 AA.
AC   B5DI68;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=FHIP family protein GA25918;
GN   ORFNames=GA25918;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SIMILARITY: Belongs to the FHIP family. {ECO:0000305}.
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DR   EMBL; CH379060; EDY70008.1; -; Genomic_DNA.
DR   RefSeq; XP_002132606.1; XM_002132570.2.
DR   AlphaFoldDB; B5DI68; -.
DR   STRING; 7237.FBpp0280448; -.
DR   PRIDE; B5DI68; -.
DR   EnsemblMetazoa; FBtr0282010; FBpp0280448; FBgn0247295.
DR   KEGG; dpo:Dpse_GA25918; -.
DR   eggNOG; KOG3695; Eukaryota.
DR   HOGENOM; CLU_007807_0_0_1; -.
DR   InParanoid; B5DI68; -.
DR   OMA; CLDWDSG; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   Bgee; FBgn0247295; Expressed in insect adult head and 2 other tissues.
DR   InterPro; IPR019384; FHIP.
DR   InterPro; IPR045669; FHIP_C.
DR   InterPro; IPR045668; FHIP_KELAA_motif.
DR   PANTHER; PTHR21705; PTHR21705; 1.
DR   Pfam; PF19314; DUF5917; 1.
DR   Pfam; PF19311; KELAA; 1.
DR   Pfam; PF10257; RAI16-like; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..1081
FT                   /note="FHIP family protein GA25918"
FT                   /id="PRO_0000379012"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          504..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          650..685
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          830..913
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          933..1027
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        656..682
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        835..879
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        890..913
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         508
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         833
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1081 AA;  118337 MW;  3EF804D8855AD7CB CRC64;
     MSWLRSSPLR QSGNGGGGGV STGHSSTGSL RQRPIDAATD CDPRACYDSF CKHWQQAYDI
     IQHYAPPTHD DVLGVVSHLD YMVTLLLVEL HHCNKVSLPS TDASAAPAAP CLEYLLSENL
     LDKLYEWACT TGRYANAVRL EQLKLYELLV SHSRHQLLCH EPFLRPLLKI LASSQGEIFP
     PDLEKRLVIL LNQLCVVLMQ NVHLLDLFFF SAQTQVQEQI QNGNVPPPKS GTTTNFIIFS
     LLIPYVHREG SLGHQARDAL LLCMALSQKN SNIGTYIAQY SSICPLLVTG LGGLYSRLPN
     SIEISSIDWH RITPDDVTEI PELTLFMNAL EFCNAVVQVA HEMIKQQLLD FMYQGFIVPV
     LGPAVLQTLK GKHFQTNIDS QISAMSYLDL ILRSITEPGL LRAFVKFLLD TEKFDGERIL
     DSLVERLNSP DANLCMVTMA LFDTLLGLHC EDLMLELLLK FMLPGKHVPI SHRHKINKID
     PYLNSSDFFL ELSPDVLKRA RDLARPKSVH EQQAPSGATG EQPIQPLAWP SLPSPVMSKT
     IGANWNYYGL HTGDSLYANL QAYLFEAHWR IAQCQRDCLK WANSYRYQKW PRHGQARVHA
     HALELARQFF SEFGGGPPAI ASESAGEKQL DSLQSIGESS GYESFKWRPA DEESDATDLT
     VTTTTASEAD LEHNSSSVSS GMGGGGGAAA GRRGEVWRIS HTNRNELLLT DLDFSEDLFA
     QGTVSLGPFL NAIWGKLQTF TSNSLYVNLH LTGLITRLAW YPLPLIHSLL LRSDIAITSD
     TPSFHQVLRI LKQQIDAELP VTEDSLEIID VARSSLIDRE FRLVNARKGN ENSPLHHHQQ
     PQTTLSQQQQ QQQGQQRSAY ATLSAATPVQ ATQTSAYDPF KRSDNKRKSI SKSISSMFSR
     RSTPNPPSSA ASSGLSQIYA FFTGAASTLV GNNNNNSGSG GQSQPFSSTG TGTCETSLST
     NPQSGAAAAR STGTATTANG NSSNSNISIG GSTQTLSGHS NTTTYSSSTL HGLDGGPQTG
     SFNSEPASLD SVASMGIIAS TSGTERTRDV ALCAVLLDEW LKELAAIAQE QSVVLVTDQL
     L