ID   U522A_DICDI             Reviewed;         506 AA.
AC   Q54JE8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=UPF0522 protein A;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0288095;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0522 family. {ECO:0000305}.
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DR   EMBL; AAFI02000109; EAL63392.1; -; Genomic_DNA.
DR   RefSeq; XP_636902.1; XM_631810.1.
DR   AlphaFoldDB; Q54JE8; -.
DR   SMR; Q54JE8; -.
DR   PaxDb; Q54JE8; -.
DR   ABCD; Q54JE8; 4 sequenced antibodies.
DR   EnsemblProtists; EAL63392; EAL63392; DDB_G0288095.
DR   GeneID; 8626457; -.
DR   KEGG; ddi:DDB_G0288095; -.
DR   dictyBase; DDB_G0288095; bpiA.
DR   eggNOG; ENOG502SSE2; Eukaryota.
DR   HOGENOM; CLU_542317_0_0_1; -.
DR   InParanoid; Q54JE8; -.
DR   OMA; QWNYHIC; -.
DR   PhylomeDB; Q54JE8; -.
DR   Reactome; R-DDI-166016; Toll Like Receptor 4 (TLR4) Cascade.
DR   Reactome; R-DDI-5686938; Regulation of TLR by endogenous ligand.
DR   PRO; PR:Q54JE8; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR032942; BPI/LBP/Plunc.
DR   PANTHER; PTHR10504; PTHR10504; 1.
DR   SUPFAM; SSF55394; SSF55394; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..506
FT                   /note="UPF0522 protein A"
FT                   /id="PRO_0000319963"
FT   CARBOHYD        145
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        155
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        330
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        366
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        418
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        427
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   506 AA;  54184 MW;  A1E525CE4FABC7C9 CRC64;
     MIKSLLLLIS IIIGIVISQE GAYPPAGIYV GLSSNFLTTE GESLTTYAQN ELLSMSLPDQ
     SGSSSKASYT FTSFKLGLTL DNIFYNQLQT DVYQIGWETI SFELQWNYHI CANAIFNPCE
     NGNIQVGTVS GASAAVASNV YVEFNSTSTS IIATNTTMAF DQGAVQVNVH CSNAICVIPV
     SDIANEVAQN FVTELTNGIT KAINEQVPTI EALFTPIKQI PMTLSNGDSF WINLEGTLVE
     ESNPTADLPT ITAALNGGVI LENTDGNFVY PSQIPSYIPT DSQLESFTSD YSIVVTGFFI
     ESLFDAVFAS ALPMTINPSQ VPSASPVQLN TSDGFFSGVA PGLSQYPNLG IQVNCYSPVT
     PLVSINSSAI SLFNLELSAD FIILNGDNPF TAFTVLFTID ASLSTEILTD SPSTFSLNST
     LASMTPNATI VTSTIGSVDA TGFVQLMQMV QGVIKLPSPA YSVPSKYSMS NVELQLGTQV
     IQITFDLIDS SLLEKQKIIK KSINFN