ID   U522B_DICDI             Reviewed;         517 AA.
AC   Q54JE7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=UPF0522 protein B;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0288097;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0522 family. {ECO:0000305}.
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DR   EMBL; AAFI02000109; EAL63393.1; -; Genomic_DNA.
DR   RefSeq; XP_636903.1; XM_631811.1.
DR   AlphaFoldDB; Q54JE7; -.
DR   SMR; Q54JE7; -.
DR   PaxDb; Q54JE7; -.
DR   EnsemblProtists; EAL63393; EAL63393; DDB_G0288097.
DR   GeneID; 8626458; -.
DR   KEGG; ddi:DDB_G0288097; -.
DR   dictyBase; DDB_G0288097; bpiB.
DR   eggNOG; ENOG502SSE2; Eukaryota.
DR   HOGENOM; CLU_542317_0_0_1; -.
DR   InParanoid; Q54JE7; -.
DR   OMA; CITITGY; -.
DR   PhylomeDB; Q54JE7; -.
DR   Reactome; R-DDI-166016; Toll Like Receptor 4 (TLR4) Cascade.
DR   Reactome; R-DDI-5686938; Regulation of TLR by endogenous ligand.
DR   PRO; PR:Q54JE7; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR032942; BPI/LBP/Plunc.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   PANTHER; PTHR10504; PTHR10504; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   SUPFAM; SSF55394; SSF55394; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..517
FT                   /note="UPF0522 protein B"
FT                   /id="PRO_0000319964"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        245
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        333
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        345
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        370
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        423
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        432
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        495
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   517 AA;  56409 MW;  8F89976CD3FBC1A0 CRC64;
     MNKTIILLLI SIIFEIVISS SVDGNYPAGG LYFGVSSNFL VGESEKFTQY VQDELLAMDL
     PDQSGDSDGV QYSFTHFKLA LNLQDFFYAQ LGPGVFQMGW DTITFNLQWE YEICVKKVVK
     LCESGTITVY TASGQSVSLG TTLDVLFNSS NAKIEATSTV MPFEAGAVVA SVHCTDSVCL
     IPINDIVSEV SSQFVSQVTN GVTKAINDKA PSIEQLFTPI KQIPITMDSG NQYWIDLEGC
     LVEANYSSNS PSTITAAING GIVLENTDGN FVYPTQTPSY VPYDSQMESF TSDYCITITG
     YFIETLLDAV LVPEFPMTIQ PSQIPASSPV QLNTSSDFFS GIAPNLTSKY PNVGIQVNLM
     PPTIPTVTIN SSAIILTDFE ISTSFLVLTD NDDAIPVFNV LFKFDAEIQT TLYTDSVSVF
     SLNSTLLSIT PNVTITDSNV GSVDATGFVQ LIEMAQSIIK IPSITYPVPS KYSITNVNSQ
     LGDQIIQLTF DLIENSTNQK YLKKSVNLNL KKKKKKK