ID   U522C_DICDI             Reviewed;         503 AA.
AC   Q55BA2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=UPF0522 protein C;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0271242;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0522 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000006; EAL71751.1; -; Genomic_DNA.
DR   RefSeq; XP_645710.1; XM_640618.1.
DR   AlphaFoldDB; Q55BA2; -.
DR   SMR; Q55BA2; -.
DR   STRING; 44689.DDB0202799; -.
DR   PaxDb; Q55BA2; -.
DR   ABCD; Q55BA2; 2 sequenced antibodies.
DR   EnsemblProtists; EAL71751; EAL71751; DDB_G0271242.
DR   GeneID; 8617903; -.
DR   KEGG; ddi:DDB_G0271242; -.
DR   dictyBase; DDB_G0271242; bpiC.
DR   eggNOG; ENOG502RBPA; Eukaryota.
DR   HOGENOM; CLU_542317_0_0_1; -.
DR   InParanoid; Q55BA2; -.
DR   OMA; CDKTHDI; -.
DR   PhylomeDB; Q55BA2; -.
DR   Reactome; R-DDI-166016; Toll Like Receptor 4 (TLR4) Cascade.
DR   Reactome; R-DDI-5686938; Regulation of TLR by endogenous ligand.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-6803157; Antimicrobial peptides.
DR   PRO; PR:Q55BA2; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:dictyBase.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR032942; BPI/LBP/Plunc.
DR   InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR   PANTHER; PTHR10504; PTHR10504; 1.
DR   Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR   SMART; SM00329; BPI2; 1.
DR   SUPFAM; SSF55394; SSF55394; 2.
PE   3: Inferred from homology;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..503
FT                   /note="UPF0522 protein C"
FT                   /id="PRO_0000319965"
FT   CARBOHYD        330
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        337
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        370
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   503 AA;  54423 MW;  0EDC41EB45590005 CRC64;
     MKLFILIILS ICLALVNSQQ GVYPDSGVYV SLNSNFLATF GNEFTQTIQN QINSYPVANV
     DGKTGKVSYS VTNIQQSVQL GDFFFQQTGV NTYNIGWNSV TFTITTDYQG CYKIGGLKKL
     SICEKGDIKI NSQATLSLSI AMTIDFTQST PTISCSSTTL NVPANGINYN VHCSSKVCDK
     THDITNEIAS KFVPSVESGM TTEINNNVGK YLSLFPSLRD MNMEYNGNEF YLDSRGTIVE
     SSQGGVLTPT MVLAMNGGIV VKNSAGQFIY PTQSPSSLPS EEAVEDFQTD IAVTLTPYLF
     ESLVDAMFES ALPMTITPSE VPSESPVHLN TSDPFFNQTA PGLTGKYPNS PIDVEIISPS
     SSSQTMVSIN STGVLVGLHS IPVNFIVNDE TVFQILFNFN IELTPALSQS SNGISVTGTL
     DKLDALVTVG STSVGDIDVS GFVQLIELAQ GLVKIPTITI QNPLTTYSLS DLSLSIGDQY
     IQILGNLQQQ QQQQQKQKQI LIK