ID   C76A1_SOLME             Reviewed;         467 AA.
AC   P37121;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Cytochrome P450 76A1;
DE            EC=1.14.-.-;
DE   AltName: Full=CYPLXXVIA1;
DE   AltName: Full=Cytochrome P-450EG8;
DE   Flags: Fragment;
GN   Name=CYP76A1; Synonyms=CYPEG8;
OS   Solanum melongena (Eggplant) (Aubergine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX   NCBI_TaxID=4111;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Sinsadoharanasu; TISSUE=Hypocotyl;
RX   PubMed=8218411; DOI=10.1016/0167-4781(93)90058-l;
RA   Toguri T., Kobayashi O., Umemoto N.;
RT   "The cloning of eggplant seedling cDNAs encoding proteins from a novel
RT   cytochrome P-450 family (CYP76).";
RL   Biochim. Biophys. Acta 1216:165-169(1993).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; X71658; CAA50649.1; -; mRNA.
DR   PIR; S38535; S38535.
DR   AlphaFoldDB; P37121; -.
DR   SMR; P37121; -.
DR   KEGG; ag:CAA50649; -.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase.
FT   CHAIN           <1..467
FT                   /note="Cytochrome P450 76A1"
FT                   /id="PRO_0000052138"
FT   BINDING         410
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   467 AA;  53288 MW;  D9A9B38DB5BF2108 CRC64;
     FGNMFDLAGS APYKKIACLK EKYGPILWLK IGSSMNTMVI QTANSASELF RNHDVSFSDR
     PIVDVNLAHN YYKGSMALAP YGNYWRFSRR ICTVEMFVHK RINETTNIRQ ESVDKMLRLD
     EEKASSSGGG GEGIEVTRYM FLASFNMVGN MIFSKDLVTD PESKQGSEFF NAMIGIMEWA
     GVPNISDIFP CLKMFDVQGL RKKMERDMGK GKEITKKFIE ERIEERKKGE KNRSIKDLLD
     VLIDFEGSGK DEPDKLSEDE ITVIILEMFL AGTETTSSSV EWALTELLRH PQAMAKVKLE
     ILQVIGPNKK FEECDIDSLP YMQAVLKEQL RLHPPLPLLI PRKAIQDTKF MGYDIPKGTQ
     VLVNAWAIGR DPEYWDNPFE FKPERFLESK VDVKGQNYEL IPFGAGRRMC VGLPLGHRMM
     HFTFGSLLHE FDWELPHNVS PKSINMEESM GITARKKQPL KVIPKKA