U587_DROME
ID U587_DROME Reviewed; 163 AA.
AC A1Z9A2; Q8MRY1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=UPF0587 protein CG4646;
GN ORFNames=CG4646;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- DOMAIN: Requires a bound zinc ion for normal folding and solubility.
CC {ECO:0000250|UniProtKB:Q9NWV4}.
CC -!- SIMILARITY: Belongs to the UPF0587 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF58406.2; -; Genomic_DNA.
DR EMBL; AY119205; AAM51065.1; -; mRNA.
DR RefSeq; NP_001286382.1; NM_001299453.1.
DR RefSeq; NP_610848.1; NM_137004.4.
DR AlphaFoldDB; A1Z9A2; -.
DR SMR; A1Z9A2; -.
DR BioGRID; 62222; 2.
DR IntAct; A1Z9A2; 1.
DR STRING; 7227.FBpp0086877; -.
DR PaxDb; A1Z9A2; -.
DR PRIDE; A1Z9A2; -.
DR EnsemblMetazoa; FBtr0087764; FBpp0086877; FBgn0033810.
DR EnsemblMetazoa; FBtr0345470; FBpp0311588; FBgn0033810.
DR GeneID; 36459; -.
DR KEGG; dme:Dmel_CG4646; -.
DR UCSC; CG4646-RA; d. melanogaster.
DR FlyBase; FBgn0033810; CG4646.
DR VEuPathDB; VectorBase:FBgn0033810; -.
DR eggNOG; KOG1296; Eukaryota.
DR GeneTree; ENSGT00390000001523; -.
DR HOGENOM; CLU_114688_1_0_1; -.
DR InParanoid; A1Z9A2; -.
DR OMA; FFMKCKM; -.
DR OrthoDB; 1398309at2759; -.
DR PhylomeDB; A1Z9A2; -.
DR BioGRID-ORCS; 36459; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 36459; -.
DR PRO; PR:A1Z9A2; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033810; Expressed in wing disc and 20 other tissues.
DR ExpressionAtlas; A1Z9A2; baseline and differential.
DR Genevisible; A1Z9A2; DM.
DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR InterPro; IPR008584; CXXC_Zn-binding_euk.
DR PANTHER; PTHR12857; PTHR12857; 1.
DR Pfam; PF05907; DUF866; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..163
FT /note="UPF0587 protein CG4646"
FT /id="PRO_0000337875"
FT BINDING 33
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9NWV4"
FT BINDING 36
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9NWV4"
FT BINDING 68
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9NWV4"
FT BINDING 71
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:Q9NWV4"
FT CONFLICT 88
FT /note="T -> M (in Ref. 3; AAM51065)"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="E -> D (in Ref. 3; AAM51065)"
FT /evidence="ECO:0000305"
FT CONFLICT 136
FT /note="D -> V (in Ref. 3; AAM51065)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 163 AA; 18606 MW; 9040A38C5763E814 CRC64;
MVRVGLQISA TLENVDKLET SHPDYSFFLK LKCSNCGEQS DKWHDITESE RVQQDSRNAA
GFNFFMKCKM CSRENSIDIV DKSNAPYTAD DSGAFKTIVV FECRGAEPVE FSPRVGWRVS
SAENGQQFEE VDLSEDDWVE YDQKNNNSVG IYEFASKFIK LKK
