ID   U63A_CONCL              Reviewed;          78 AA.
AC   D2Y493;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Conotoxin Cal6.3a {ECO:0000303|PubMed:21172372};
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
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DR   EMBL; GU306157; ADB04236.1; -; mRNA.
DR   AlphaFoldDB; D2Y493; -.
DR   ConoServer; 3967; Cal6.3a precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..26
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000566312"
FT   PEPTIDE         31..76
FT                   /note="Conotoxin Cal6.3a"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000566313"
FT   MOD_RES         76
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..49
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        48..56
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  9104 MW;  636B6C8E9FAADBB4 CRC64;
     MRFLHFLIVA VLLASFMESG AMPRNPKKKR GWDTPAPCRY CQWNGPQCCV YYCSSCNYEE
     AREEGHYVSS HLLERQGR