ID   U63B_CONCL              Reviewed;          52 AA.
AC   D2Y494;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Conotoxin Cal6.3b {ECO:0000303|PubMed:21172372};
DE   Flags: Precursor; Fragment;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
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DR   EMBL; GU306158; ADB04237.1; -; mRNA.
DR   AlphaFoldDB; D2Y494; -.
DR   ConoServer; 3968; Cal6.3b precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin.
FT   PROPEP          <1..4
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_0000417989"
FT   PEPTIDE         5..50
FT                   /note="Conotoxin Cal6.3b"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000566315"
FT   MOD_RES         50
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        12..23
FT                   /evidence="ECO:0000250"
FT   DISULFID        15..27
FT                   /evidence="ECO:0000250"
FT   DISULFID        22..30
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   52 AA;  6169 MW;  E58374881164267A CRC64;
     KKKRGWDTPA PCHYCQWKGP QCCVYYCSSC NYEEAREEGH YVSSHLLERQ GR