ID   U652_DICDI              Reviewed;         677 AA.
AC   Q54BM8;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=UPF0652 protein;
GN   ORFNames=DDB_G0293552;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the UPF0652 family. {ECO:0000305}.
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DR   EMBL; AAFI02000218; EAL60588.1; -; Genomic_DNA.
DR   RefSeq; XP_629001.1; XM_628999.1.
DR   AlphaFoldDB; Q54BM8; -.
DR   PaxDb; Q54BM8; -.
DR   EnsemblProtists; EAL60588; EAL60588; DDB_G0293552.
DR   GeneID; 8629285; -.
DR   KEGG; ddi:DDB_G0293552; -.
DR   dictyBase; DDB_G0293552; -.
DR   eggNOG; ENOG502QRJJ; Eukaryota.
DR   HOGENOM; CLU_021807_0_0_1; -.
DR   InParanoid; Q54BM8; -.
DR   OMA; DAFAHMF; -.
DR   PhylomeDB; Q54BM8; -.
DR   PRO; PR:Q54BM8; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR018553; DUF2009.
DR   InterPro; IPR000315; Znf_B-box.
DR   PANTHER; PTHR31560; PTHR31560; 1.
DR   Pfam; PF09418; DUF2009; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..677
FT                   /note="UPF0652 protein"
FT                   /id="PRO_0000350764"
FT   ZN_FING         38..84
FT                   /note="B box-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   REGION          91..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          156..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..111
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         43
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         46
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         66
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ   SEQUENCE   677 AA;  78291 MW;  3751D1C8B5F0FC87 CRC64;
     MSKQNKLTKV LDNDLDDIDI EEDDSTNRKF ESMSEDEETP GMCCECTDQP AEVVCLQCQD
     ELCTVCSTSL HRRGSRRSHI FKNKHGQELD YDELNKRDRQ PPLHGKEDEK VQNNNNNNNN
     TNNTNNIEMD DNKSINNNNN NINSINSMYR GTSNLLNPLP FHHTNQQRNG GGSNNHQINN
     HHKDEDEEID EDEEKFIHKN ENFTDFIPRL SKDWFTERSK YIPIRLNIRE RNDLRLLEAA
     LHVSEYTDKI DIIHVGGSKS KRINDQLRGM CAILSGLLVA SDFKKGQQLV ENKDFFENEE
     FFQNVFEIGR RHKIMNPAKM RTEYGKMIHL LQDAADEDVK KNLSGLNMIK PLKTVFLFLD
     ERNGLKLLED PLLELATREV LAENKTRPQI QREIREKEHA IKTLSRRYSS SMLKSEEIEV
     CIYSICDNHT FLRENRDPVK KMKHLLKEYF SPNQSERGFS LALEHGIGGA RLSHNHRKQY
     NYVYQSLSLW QHILHDMFKL WYFAEIDLLC GHRYQLSNTG QGLNRIQQCP NVGKIMHSIL
     RQTQKKVGDD WVGSSVIHLG DHNVPNSLVF IDKYTQISRI LSPIVLTIEY IPKITDPNLV
     AYIKNTFGGP QTLTKIILCD FFKHAFDGSG ADNFFDAGSC IDGRLTSAWQ WSAQIAKKPY
     YPIFLLSGFS GFDGSFN