ID   U6A_CONCL               Reviewed;          28 AA.
AC   P0DJB8;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Conotoxin Cl6a {ECO:0000303|PubMed:20363338};
DE   AltName: Full=Cal6.43a {ECO:0000305};
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA   Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA   Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA   Olivera B.M.;
RT   "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT   1844.";
RL   Mol. Phylogenet. Evol. 56:1-12(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
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DR   AlphaFoldDB; P0DJB8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..28
FT                   /note="Conotoxin Cl6a"
FT                   /id="PRO_0000415054"
FT   DISULFID        3..13
FT                   /evidence="ECO:0000250"
FT   DISULFID        7..19
FT                   /evidence="ECO:0000250"
FT   DISULFID        12..24
FT                   /evidence="ECO:0000250"
FT   UNSURE          28
FT                   /note="N or D"
SQ   SEQUENCE   28 AA;  2999 MW;  A95C1BD798B31568 CRC64;
     DDCTTYCYGV HCCPPAFKCA ASGCVRNN