ID   U6A_CONPI               Reviewed;          29 AA.
AC   P0CH17;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Conotoxin pr6a {ECO:0000303|PubMed:20570703};
OS   Conus parius (Cone snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX   NCBI_TaxID=505247;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=20570703; DOI=10.1016/j.peptides.2010.05.020;
RA   Jimenez E.C., Olivera B.M.;
RT   "Divergent M- and O-superfamily peptides from venom of fish-hunting Conus
RT   parius.";
RL   Peptides 31:1678-1683(2010).
CC   -!- FUNCTION: Intraperitoneal injection into fish (1 nmol) provokes
CC       hyperactivity and erratic swimming in various directions after 14 min.
CC       {ECO:0000269|PubMed:20570703}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20570703}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:20570703}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3090.4; Method=MALDI; Note=Monoisotopic mass.;
CC       Evidence={ECO:0000269|PubMed:20570703};
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DR   AlphaFoldDB; P0CH17; -.
DR   SMR; P0CH17; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Neurotoxin; Secreted;
KW   Toxin.
FT   PEPTIDE         1..29
FT                   /note="Conotoxin pr6a"
FT                   /evidence="ECO:0000269|PubMed:20570703"
FT                   /id="PRO_0000397115"
FT   DISULFID        2..20
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..24
FT                   /evidence="ECO:0000250"
FT   DISULFID        19..28
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   29 AA;  3097 MW;  538212B03C0499F2 CRC64;
     TCLARDELCG ASFLSNFLCC DGLCLLICV