ID   U6A_CONSP               Reviewed;          32 AA.
AC   P0C352;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Conotoxin sr7a;
OS   Conus spurius (Alphabet cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lindaconus.
OX   NCBI_TaxID=192919;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AMIDATION AT
RP   SER-32, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=17166626; DOI=10.1016/j.peptides.2006.08.025;
RA   Luna-Ramirez K.S., Aguilar M.B., Falcon A., Heimer de la Cotera E.P.,
RA   Olivera B.M., Maillo M.;
RT   "An O-conotoxin from the vermivorous Conus spurius active on mice and
RT   mollusks.";
RL   Peptides 28:24-30(2007).
CC   -!- FUNCTION: Elicits hyperactivity when injected intracranially into mice
CC       and produces paralysis when injected into the pedal muscle of
CC       freshwater snails, Pomacea paludosa, but it has no apparent effect
CC       after intramuscular injection into the limpet Patella opea or the
CC       freshwater fish Lebistes reticulatus.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17166626}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:17166626}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- MASS SPECTROMETRY: Mass=3329.74; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:17166626};
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DR   AlphaFoldDB; P0C352; -.
DR   SMR; P0C352; -.
DR   ConoServer; 1450; SrVIIA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Knottin; Neurotoxin;
KW   Secreted; Toxin.
FT   PEPTIDE         1..32
FT                   /note="Conotoxin sr7a"
FT                   /id="PRO_0000288947"
FT   MOD_RES         32
FT                   /note="Serine amide"
FT                   /evidence="ECO:0000269|PubMed:17166626"
FT   DISULFID        1..17
FT                   /evidence="ECO:0000250"
FT   DISULFID        8..21
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..31
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   32 AA;  3337 MW;  5AF71686F6926D7F CRC64;
     CLQFGSTCFL GDDDICCSGE CFYSGGTFGI CS