U729_DROME
ID U729_DROME Reviewed; 99 AA.
AC O97172; Q32UZ2;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=UPF0729 protein CG18508;
GN ORFNames=CG18508;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASN-72.
RC STRAIN=Us13, Usa1, Usa11, Usa12, Usa15, Usa16, Usa17, Usa18, Usa2, Usa3,
RC Usa4, Usa6, Usa7, Usa8, Usa9, Z36, Z50, Zim10, Zim13, Zim15, Zim16, Zim18,
RC Zim22, Zim39, Zim41, Zim42, and Zim7;
RX PubMed=16020794; DOI=10.1534/genetics.104.038851;
RA DuMont V.B., Aquadro C.F.;
RT "Multiple signatures of positive selection downstream of notch on the X
RT chromosome in Drosophila melanogaster.";
RL Genetics 171:639-653(2005).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the UPF0729 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF45849.1; -; Genomic_DNA.
DR EMBL; AL035395; CAB37612.1; -; Genomic_DNA.
DR EMBL; AY795911; AAY27430.1; -; Genomic_DNA.
DR EMBL; AY795912; AAY27435.1; -; Genomic_DNA.
DR EMBL; AY795913; AAY27439.1; -; Genomic_DNA.
DR EMBL; AY795914; AAY27443.1; -; Genomic_DNA.
DR EMBL; AY795915; AAY27447.1; -; Genomic_DNA.
DR EMBL; AY795916; AAY27451.1; -; Genomic_DNA.
DR EMBL; AY795917; AAY27455.1; -; Genomic_DNA.
DR EMBL; AY795918; AAY27459.1; -; Genomic_DNA.
DR EMBL; AY795919; AAY27463.1; -; Genomic_DNA.
DR EMBL; AY795920; AAY27467.1; -; Genomic_DNA.
DR EMBL; AY795921; AAY27471.1; -; Genomic_DNA.
DR EMBL; AY795922; AAY27475.1; -; Genomic_DNA.
DR EMBL; AY795923; AAY27479.1; -; Genomic_DNA.
DR EMBL; AY795924; AAY27483.1; -; Genomic_DNA.
DR EMBL; AY795925; AAY27487.1; -; Genomic_DNA.
DR EMBL; AY795926; AAY27491.1; -; Genomic_DNA.
DR EMBL; AY795927; AAY27495.1; -; Genomic_DNA.
DR EMBL; AY795928; AAY27499.1; -; Genomic_DNA.
DR EMBL; AY795929; AAY27503.1; -; Genomic_DNA.
DR EMBL; AY795930; AAY27507.1; -; Genomic_DNA.
DR EMBL; AY795931; AAY27511.1; -; Genomic_DNA.
DR EMBL; AY795932; AAY27515.1; -; Genomic_DNA.
DR EMBL; AY795933; AAY27519.1; -; Genomic_DNA.
DR EMBL; AY795934; AAY27523.1; -; Genomic_DNA.
DR EMBL; AY795935; AAY27527.1; -; Genomic_DNA.
DR EMBL; AY795936; AAY27531.1; -; Genomic_DNA.
DR EMBL; AY795937; AAY27535.1; -; Genomic_DNA.
DR RefSeq; NP_001284836.1; NM_001297907.1.
DR RefSeq; NP_652721.1; NM_144464.3.
DR AlphaFoldDB; O97172; -.
DR IntAct; O97172; 62.
DR iPTMnet; O97172; -.
DR PaxDb; O97172; -.
DR DNASU; 59253; -.
DR EnsemblMetazoa; FBtr0070543; FBpp0070518; FBgn0028746.
DR EnsemblMetazoa; FBtr0345708; FBpp0311752; FBgn0028746.
DR GeneID; 59253; -.
DR KEGG; dme:Dmel_CG18508; -.
DR UCSC; CG18508-RA; d. melanogaster.
DR FlyBase; FBgn0028746; CG18508.
DR VEuPathDB; VectorBase:FBgn0028746; -.
DR eggNOG; ENOG502SEY0; Eukaryota.
DR HOGENOM; CLU_167079_0_0_1; -.
DR InParanoid; O97172; -.
DR OMA; KGPDFPF; -.
DR OrthoDB; 1627271at2759; -.
DR PhylomeDB; O97172; -.
DR BioGRID-ORCS; 59253; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 59253; -.
DR PRO; PR:O97172; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0028746; Expressed in seminal fluid secreting gland and 25 other tissues.
DR ExpressionAtlas; O97172; baseline and differential.
DR Genevisible; O97172; DM.
DR InterPro; IPR026776; UPF0729.
DR PANTHER; PTHR13456; PTHR13456; 1.
DR Pfam; PF14975; DUF4512; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..99
FT /note="UPF0729 protein CG18508"
FT /id="PRO_0000365093"
FT REGION 60..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 69
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VARIANT 72
FT /note="D -> N (in strain: Usa7, Z36, Z50, Zim7, Zim10,
FT Zim13, Zim15, Zim16, Zim18, Zim39 Zim41 and Zim42)"
FT /evidence="ECO:0000269|PubMed:16020794"
SQ SEQUENCE 99 AA; 11150 MW; 0BF00050D1F11758 CRC64;
MVCVPCIIIP LLLYIWHKFV QPILLRYWNP WEKKDDDGNV IKKGPDFPFE CKGGVCPFVP
GGKKTENVSD DDAEESENPP LNATAMAAET EVDESKKEI
