U73B1_ARATH
ID U73B1_ARATH Reviewed; 488 AA.
AC Q8VZE9;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=UDP-glycosyltransferase 73B1;
DE EC=2.4.1.-;
GN Name=UGT73B1; OrderedLocusNames=At4g34138; ORFNames=F28A23.110;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=11042215; DOI=10.1074/jbc.m007447200;
RA Li Y., Baldauf S., Lim E.K., Bowles D.J.;
RT "Phylogenetic analysis of the UDP-glycosyltransferase multigene family of
RT Arabidopsis thaliana.";
RL J. Biol. Chem. 276:4338-4343(2001).
RN [5]
RP FUNCTION.
RX PubMed=15352060; DOI=10.1002/bit.20154;
RA Lim E.K., Ashford D.A., Hou B., Jackson R.G., Bowles D.J.;
RT "Arabidopsis glycosyltransferases as biocatalysts in fermentation for
RT regioselective synthesis of diverse quercetin glucosides.";
RL Biotechnol. Bioeng. 87:623-631(2004).
RN [6]
RP INDUCTION BY PATHOGEN AND SALICYLIC ACID.
RX PubMed=16306146; DOI=10.1104/pp.105.067223;
RA Langlois-Meurinne M., Gachon C.M., Saindrenan P.;
RT "Pathogen-responsive expression of glycosyltransferase genes UGT73B3 and
RT UGT73B5 is necessary for resistance to Pseudomonas syringae pv tomato in
RT Arabidopsis.";
RL Plant Physiol. 139:1890-1901(2005).
CC -!- FUNCTION: Possesses low quercetin 3-O-glucosyltransferase and 7-O-
CC glucosyltransferase activities in vitro. {ECO:0000269|PubMed:15352060}.
CC -!- INDUCTION: Not induced by pathogen or salicylic acid.
CC {ECO:0000269|PubMed:16306146}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000305}.
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DR EMBL; AL161584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002687; AEE86330.1; -; Genomic_DNA.
DR EMBL; AY065005; AAL57652.1; -; mRNA.
DR EMBL; AY090273; AAL90934.1; -; mRNA.
DR EMBL; BT000754; AAN31894.1; -; mRNA.
DR RefSeq; NP_567955.1; NM_119576.4.
DR AlphaFoldDB; Q8VZE9; -.
DR SMR; Q8VZE9; -.
DR STRING; 3702.AT4G34138.1; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR PaxDb; Q8VZE9; -.
DR PRIDE; Q8VZE9; -.
DR ProteomicsDB; 242589; -.
DR EnsemblPlants; AT4G34138.1; AT4G34138.1; AT4G34138.
DR GeneID; 829561; -.
DR Gramene; AT4G34138.1; AT4G34138.1; AT4G34138.
DR KEGG; ath:AT4G34138; -.
DR Araport; AT4G34138; -.
DR TAIR; locus:505006556; AT4G34138.
DR eggNOG; KOG1192; Eukaryota.
DR HOGENOM; CLU_001724_2_2_1; -.
DR InParanoid; Q8VZE9; -.
DR OMA; MIPTIAM; -.
DR OrthoDB; 508327at2759; -.
DR PhylomeDB; Q8VZE9; -.
DR BioCyc; ARA:AT4G34138-MON; -.
DR BRENDA; 2.4.1.170; 399.
DR BRENDA; 2.4.1.81; 399.
DR PRO; PR:Q8VZE9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8VZE9; baseline and differential.
DR Genevisible; Q8VZE9; AT.
DR GO; GO:0080043; F:quercetin 3-O-glucosyltransferase activity; IDA:TAIR.
DR GO; GO:0080044; F:quercetin 7-O-glucosyltransferase activity; IDA:TAIR.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR Pfam; PF00201; UDPGT; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 2: Evidence at transcript level;
KW Glycosyltransferase; Reference proteome; Transferase.
FT CHAIN 1..488
FT /note="UDP-glycosyltransferase 73B1"
FT /id="PRO_0000403935"
FT BINDING 297
FT /ligand="UDP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:58885"
FT /evidence="ECO:0000250"
FT BINDING 356..358
FT /ligand="UDP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:58885"
FT /evidence="ECO:0000250"
FT BINDING 373..381
FT /ligand="UDP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:58885"
FT /evidence="ECO:0000250"
FT BINDING 395..398
FT /ligand="UDP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:58885"
FT /evidence="ECO:0000250"
SQ SEQUENCE 488 AA; 54836 MW; B323F404C4DF6390 CRC64;
MGTPVEVSKL HFLLFPFMAH GHMIPTLDMA KLFATKGAKS TILTTPLNAK LFFEKPIKSF
NQDNPGLEDI TIQILNFPCT ELGLPDGCEN TDFIFSTPDL NVGDLSQKFL LAMKYFEEPL
EELLVTMRPD CLVGNMFFPW STKVAEKFGV PRLVFHGTGY FSLCASHCIR LPKNVATSSE
PFVIPDLPGD ILITEEQVME TEEESVMGRF MKAIRDSERD SFGVLVNSFY ELEQAYSDYF
KSFVAKRAWH IGPLSLGNRK FEEKAERGKK ASIDEHECLK WLDSKKCDSV IYMAFGTMSS
FKNEQLIEIA AGLDMSGHDF VWVVNRKGSQ VEKEDWLPEG FEEKTKGKGL IIRGWAPQVL
ILEHKAIGGF LTHCGWNSLL EGVAAGLPMV TWPVGAEQFY NEKLVTQVLK TGVSVGVKKM
MQVVGDFISR EKVEGAVREV MVGEERRKRA KELAEMAKNA VKEGGSSDLE VDRLMEELTL
VKLQKEKV
