ID   U73C1_ARATH             Reviewed;         491 AA.
AC   Q9ZQ99; Q0V837;
DT   24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=UDP-glycosyltransferase 73C1;
DE            EC=2.4.1.-;
DE   AltName: Full=Cytokinin-O-glucosyltransferase 1;
DE   AltName: Full=Zeatin O-glucosyltransferase 1;
DE            Short=AtZOG1;
GN   Name=UGT73C1; Synonyms=ZOG1; OrderedLocusNames=At2g36750;
GN   ORFNames=F13K3.15;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Martin R.C., Mok M.C., Mok D.W.S.;
RT   "Arabidopsis genes encoding zeatin O-glucosyltransferases.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY.
RX   PubMed=11042215; DOI=10.1074/jbc.m007447200;
RA   Li Y., Baldauf S., Lim E.K., Bowles D.J.;
RT   "Phylogenetic analysis of the UDP-glycosyltransferase multigene family of
RT   Arabidopsis thaliana.";
RL   J. Biol. Chem. 276:4338-4343(2001).
RN   [6]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=15342621; DOI=10.1074/jbc.m409569200;
RA   Hou B., Lim E.-K., Higgins G.S., Bowles D.J.;
RT   "N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis
RT   thaliana.";
RL   J. Biol. Chem. 279:47822-47832(2004).
RN   [7]
RP   FUNCTION.
RX   PubMed=18702669; DOI=10.1111/j.1365-313x.2008.03653.x;
RA   Gandia-Herrero F., Lorenz A., Larson T., Graham I.A., Bowles D.J.,
RA   Rylott E.L., Bruce N.C.;
RT   "Detoxification of the explosive 2,4,6-trinitrotoluene in Arabidopsis:
RT   discovery of bifunctional O- and C-glucosyltransferases.";
RL   Plant J. 56:963-974(2008).
CC   -!- FUNCTION: Involved in the O-glucosylation of trans-zeatin and
CC       dihydrozeatin. Also active in vitro on cis-zeatin, dihydrozeatin-9-N-
CC       Glc, and olomoucine. Can detoxify the explosive 2,4,6-trinitrotoluene
CC       in plant by forming O- or C-glucose conjugates.
CC       {ECO:0000269|PubMed:15342621, ECO:0000269|PubMed:18702669}.
CC   -!- INDUCTION: Not induced by cytokinin treatment.
CC       {ECO:0000269|PubMed:15342621}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AY573820; AAS87590.1; -; Genomic_DNA.
DR   EMBL; AC006282; AAD20151.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC09294.1; -; Genomic_DNA.
DR   EMBL; BT026383; ABH04490.1; -; mRNA.
DR   PIR; C84784; C84784.
DR   RefSeq; NP_181213.1; NM_129230.3.
DR   AlphaFoldDB; Q9ZQ99; -.
DR   SMR; Q9ZQ99; -.
DR   STRING; 3702.AT2G36750.1; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PaxDb; Q9ZQ99; -.
DR   PRIDE; Q9ZQ99; -.
DR   ProteomicsDB; 228730; -.
DR   EnsemblPlants; AT2G36750.1; AT2G36750.1; AT2G36750.
DR   GeneID; 818247; -.
DR   Gramene; AT2G36750.1; AT2G36750.1; AT2G36750.
DR   KEGG; ath:AT2G36750; -.
DR   Araport; AT2G36750; -.
DR   TAIR; locus:2040590; AT2G36750.
DR   eggNOG; KOG1192; Eukaryota.
DR   HOGENOM; CLU_001724_2_2_1; -.
DR   InParanoid; Q9ZQ99; -.
DR   OMA; LLCTHIM; -.
DR   OrthoDB; 508327at2759; -.
DR   PhylomeDB; Q9ZQ99; -.
DR   BioCyc; ARA:AT2G36750-MON; -.
DR   BioCyc; MetaCyc:AT2G36750-MON; -.
DR   BRENDA; 2.4.1.203; 399.
DR   PRO; PR:Q9ZQ99; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9ZQ99; baseline and differential.
DR   Genevisible; Q9ZQ99; AT.
DR   GO; GO:0050502; F:cis-zeatin O-beta-D-glucosyltransferase activity; IDA:TAIR.
DR   GO; GO:0050403; F:trans-zeatin O-beta-D-glucosyltransferase activity; IDA:TAIR.
DR   GO; GO:0035251; F:UDP-glucosyltransferase activity; IDA:TAIR.
DR   GO; GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
DR   GO; GO:0010224; P:response to UV-B; IEP:TAIR.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Detoxification; Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..491
FT                   /note="UDP-glycosyltransferase 73C1"
FT                   /id="PRO_0000074155"
FT   BINDING         292
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   BINDING         352..354
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   BINDING         369..377
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   BINDING         391..394
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   491 AA;  55224 MW;  27CE6A537B9D5BD4 CRC64;
     MASEFRPPLH FVLFPFMAQG HMIPMVDIAR LLAQRGVTIT IVTTPQNAGR FKNVLSRAIQ
     SGLPINLVQV KFPSQESGSP EGQENLDLLD SLGASLTFFK AFSLLEEPVE KLLKEIQPRP
     NCIIADMCLP YTNRIAKNLG IPKIIFHGMC CFNLLCTHIM HQNHEFLETI ESDKEYFPIP
     NFPDRVEFTK SQLPMVLVAG DWKDFLDGMT EGDNTSYGVI VNTFEELEPA YVRDYKKVKA
     GKIWSIGPVS LCNKLGEDQA ERGNKADIDQ DECIKWLDSK EEGSVLYVCL GSICNLPLSQ
     LKELGLGLEE SQRPFIWVIR GWEKYNELLE WISESGYKER IKERGLLITG WSPQMLILTH
     PAVGGFLTHC GWNSTLEGIT SGVPLLTWPL FGDQFCNEKL AVQILKAGVR AGVEESMRWG
     EEEKIGVLVD KEGVKKAVEE LMGDSNDAKE RRKRVKELGE LAHKAVEEGG SSHSNITFLL
     QDIMQLEQPK K