C76C3_ARATH
ID C76C3_ARATH Reviewed; 515 AA.
AC O64638; Q8GXM0;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Cytochrome P450 76C3;
DE EC=1.14.-.-;
GN Name=CYP76C3; OrderedLocusNames=At2g45580; ORFNames=F17K2.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC06159.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC003680; AAC06159.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002685; AEC10573.1; -; Genomic_DNA.
DR EMBL; AK118163; BAC42787.1; -; mRNA.
DR PIR; T00871; T00871.
DR RefSeq; NP_182082.2; NM_130120.4.
DR AlphaFoldDB; O64638; -.
DR SMR; O64638; -.
DR BioGRID; 4502; 1.
DR IntAct; O64638; 1.
DR STRING; 3702.AT2G45580.1; -.
DR PaxDb; O64638; -.
DR ProteomicsDB; 240262; -.
DR EnsemblPlants; AT2G45580.1; AT2G45580.1; AT2G45580.
DR GeneID; 819166; -.
DR Gramene; AT2G45580.1; AT2G45580.1; AT2G45580.
DR KEGG; ath:AT2G45580; -.
DR Araport; AT2G45580; -.
DR TAIR; locus:2043614; AT2G45580.
DR eggNOG; KOG0156; Eukaryota.
DR HOGENOM; CLU_001570_4_2_1; -.
DR InParanoid; O64638; -.
DR OMA; HEFIDDR; -.
DR OrthoDB; 1247045at2759; -.
DR PhylomeDB; O64638; -.
DR BioCyc; ARA:AT2G45580-MON; -.
DR PRO; PR:O64638; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O64638; baseline and differential.
DR Genevisible; O64638; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Heme; Iron; Membrane; Metal-binding; Monooxygenase; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..515
FT /note="Cytochrome P450 76C3"
FT /id="PRO_0000052143"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 451
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
FT CONFLICT 438
FT /note="D -> A (in Ref. 3; BAC42787)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 515 AA; 58143 MW; EA3973EAB0D60F25 CRC64;
MDLSLIQGMS LPLYFLLTLF FFFFATAKTR RSSSTGTLPP GPPILPLVGN IFQLGFNPHR
SLAAFSKTYG PIMSLKLGRL TAVVISSPEA AKEALRTHDH VMSARTFNDA LRAFDHHKHS
IVWIPPSARW RFLKKTITKY LLSPQNLDAI QSLRMRKVEE LVSLVNEFRE RGEAIDLARA
SFVTSFNIIS NALFSVDLAT YDSNSSSYEF HNTVVHLTDI AGIPNVGDYF QYMRFLDLQG
TRKKAVLCIE KLFRVFQEFI DARLAKRFSR TEKEPKEASS IDMLDSLLDL TQQNEAELTM
NDLKHLLLDV FVAGTDTNSS TMEWAMTELF RSTEKMVKAQ SEIRQVIGQN GFVQESDIPS
LPYLQAIVKE TLRLHPAAPL IPRKSESDVQ IMGFLVPKNT QVVVNVWAIG RDASVWENPM
KFEPERFLLR ETDVKGRDFE LIPFGSGRRM CPGISMALKT MHMVLASLLY SFDWKLQNGV
VPGNIDMSET FGLTLHKAKS LCAVPVKKPT ISSSY
