U75D1_ARATH
ID U75D1_ARATH Reviewed; 474 AA.
AC O23406; O04930; Q93Z19;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=UDP-glycosyltransferase 75D1;
DE EC=2.4.1.-;
GN Name=UGT75D1; Synonyms=IAGLU; OrderedLocusNames=At4g15550;
GN ORFNames=dl3815c, FCAALL.103;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Graham R.A., Thornburg R.W.;
RT "DNA sequence of UDP glucose:indole-3-acetate beta-D-glucosyltransferase
RT from Arabidopsis thaliana.";
RL (er) Plant Gene Register PGR97-044(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-474.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=11042215; DOI=10.1074/jbc.m007447200;
RA Li Y., Baldauf S., Lim E.K., Bowles D.J.;
RT "Phylogenetic analysis of the UDP-glycosyltransferase multigene family of
RT Arabidopsis thaliana.";
RL J. Biol. Chem. 276:4338-4343(2001).
RN [7]
RP FUNCTION.
RX PubMed=12721858; DOI=10.1007/s00425-002-0969-0;
RA Messner B., Thulke O., Schaeffner A.R.;
RT "Arabidopsis glucosyltransferases with activities toward both endogenous
RT and xenobiotic substrates.";
RL Planta 217:138-146(2003).
CC -!- FUNCTION: Glucosyltransferase that glucosylates kaempferol. Can
CC glucosylate the phytotoxic xenobiotic compound 2,4,5-trichlorophenol
CC (TCP). {ECO:0000269|PubMed:12721858}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL24226.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB10333.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78597.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; U81293; AAB58497.1; -; mRNA.
DR EMBL; Z97339; CAB10333.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161541; CAB78597.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83624.1; -; Genomic_DNA.
DR EMBL; AY058838; AAL24226.1; ALT_INIT; mRNA.
DR EMBL; AY103297; AAM65349.1; -; mRNA.
DR PIR; C71420; C71420.
DR RefSeq; NP_567471.1; NM_117646.3.
DR AlphaFoldDB; O23406; -.
DR SMR; O23406; -.
DR STRING; 3702.AT4G15550.1; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR MetOSite; O23406; -.
DR PaxDb; O23406; -.
DR PRIDE; O23406; -.
DR ProteomicsDB; 228679; -.
DR EnsemblPlants; AT4G15550.1; AT4G15550.1; AT4G15550.
DR GeneID; 827229; -.
DR Gramene; AT4G15550.1; AT4G15550.1; AT4G15550.
DR KEGG; ath:AT4G15550; -.
DR Araport; AT4G15550; -.
DR TAIR; locus:2130359; AT4G15550.
DR eggNOG; KOG1192; Eukaryota.
DR HOGENOM; CLU_001724_0_1_1; -.
DR InParanoid; O23406; -.
DR OMA; AFADEHM; -.
DR OrthoDB; 508327at2759; -.
DR PRO; PR:O23406; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O23406; baseline and differential.
DR Genevisible; O23406; AT.
DR GO; GO:0080043; F:quercetin 3-O-glucosyltransferase activity; IBA:GO_Central.
DR GO; GO:0080044; F:quercetin 7-O-glucosyltransferase activity; IBA:GO_Central.
DR GO; GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR Pfam; PF00201; UDPGT; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 2: Evidence at transcript level;
KW Detoxification; Glycosyltransferase; Reference proteome; Transferase.
FT CHAIN 1..474
FT /note="UDP-glycosyltransferase 75D1"
FT /id="PRO_0000409081"
FT BINDING 287
FT /ligand="UDP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:58885"
FT /evidence="ECO:0000250"
FT BINDING 350..352
FT /ligand="UDP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:58885"
FT /evidence="ECO:0000250"
FT BINDING 367..375
FT /ligand="UDP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:58885"
FT /evidence="ECO:0000250"
FT BINDING 389..392
FT /ligand="UDP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:58885"
FT /evidence="ECO:0000250"
FT CONFLICT 79
FT /note="G -> V (in Ref. 5; AAL24226/AAM65349)"
FT /evidence="ECO:0000305"
FT CONFLICT 336..340
FT /note="FREEL -> SEKSF (in Ref. 1; AAB58497)"
FT /evidence="ECO:0000305"
FT CONFLICT 394
FT /note="M -> T (in Ref. 1; AAB58497)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 474 AA; 53867 MW; A8FEA7773207A519 CRC64;
MANNNSNSPT GPHFLFVTFP AQGHINPSLE LAKRLAGTIS GARVTFAASI SAYNRRMFST
ENVPETLIFA TYSDGHDDGF KSSAYSDKSR QDATGNFMSE MRRRGKETLT ELIEDNRKQN
RPFTCVVYTI LLTWVAELAR EFHLPSALLW VQPVTVFSIF YHYFNGYEDA ISEMANTPSS
SIKLPSLPLL TVRDIPSFIV SSNVYAFLLP AFREQIDSLK EEINPKILIN TFQELEPEAM
SSVPDNFKIV PVGPLLTLRT DFSSRGEYIE WLDTKADSSV LYVSFGTLAV LSKKQLVELC
KALIQSRRPF LWVITDKSYR NKEDEQEKEE DCISSFREEL DEIGMVVSWC DQFRVLNHRS
IGCFVTHCGW NSTLESLVSG VPVVAFPQWN DQMMNAKLLE DCWKTGVRVM EKKEEEGVVV
VDSEEIRRCI EEVMEDKAEE FRGNATRWKD LAAEAVREGG SSFNHLKAFV DEHM
