ID   U76E3_ARATH             Reviewed;         447 AA.
AC   Q494Q1; Q9STE4;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=UDP-glycosyltransferase 76E3;
DE            EC=2.4.1.-;
GN   Name=UGT76E3; OrderedLocusNames=At3g46700; ORFNames=T6H20.270;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY.
RX   PubMed=11042215; DOI=10.1074/jbc.m007447200;
RA   Li Y., Baldauf S., Lim E.K., Bowles D.J.;
RT   "Phylogenetic analysis of the UDP-glycosyltransferase multigene family of
RT   Arabidopsis thaliana.";
RL   J. Biol. Chem. 276:4338-4343(2001).
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB51195.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL096859; CAB51195.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE78195.1; -; Genomic_DNA.
DR   EMBL; BT023725; AAZ23917.1; -; mRNA.
DR   EMBL; AK229001; BAF00888.1; -; mRNA.
DR   PIR; T12980; T12980.
DR   RefSeq; NP_190254.2; NM_114537.4.
DR   AlphaFoldDB; Q494Q1; -.
DR   SMR; Q494Q1; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   PaxDb; Q494Q1; -.
DR   PRIDE; Q494Q1; -.
DR   ProteomicsDB; 228712; -.
DR   EnsemblPlants; AT3G46700.1; AT3G46700.1; AT3G46700.
DR   GeneID; 823823; -.
DR   Gramene; AT3G46700.1; AT3G46700.1; AT3G46700.
DR   KEGG; ath:AT3G46700; -.
DR   Araport; AT3G46700; -.
DR   TAIR; locus:2102847; AT3G46700.
DR   eggNOG; KOG1192; Eukaryota.
DR   HOGENOM; CLU_001724_0_0_1; -.
DR   InParanoid; Q494Q1; -.
DR   OMA; ICSSDWI; -.
DR   OrthoDB; 508327at2759; -.
DR   PhylomeDB; Q494Q1; -.
DR   BioCyc; ARA:AT3G46700-MON; -.
DR   PRO; PR:Q494Q1; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q494Q1; baseline and differential.
DR   Genevisible; Q494Q1; AT.
DR   GO; GO:0080043; F:quercetin 3-O-glucosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0080044; F:quercetin 7-O-glucosyltransferase activity; IBA:GO_Central.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   Pfam; PF00201; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..447
FT                   /note="UDP-glycosyltransferase 76E3"
FT                   /id="PRO_0000409088"
FT   BINDING         269
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   BINDING         328..330
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   BINDING         345..353
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   BINDING         367..370
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   447 AA;  50193 MW;  CAA91E4948DABA9B CRC64;
     MEKRVEKRRI VLVPLPLLGH FTPMMQLGQA LILKGFSIIV PQGEFNRVNS SQKFPGFQFI
     TIPDSELEAN GPVGSLTQLN KIMEASFKDC IRQLLKQQGN DIACIIYDEF MYFCGAVAEE
     LKLPNFIFST QTATHKVCCN VLSKLNAKKY LIDMEEHDVQ NKVVENMHPL RYKDLPTATF
     GELEPFLELC RDVVNKRTAS AVIINTVTCL ESSSLTRLQQ ELQIPVYPLG PLHITDSSTG
     FTVLQEDRSC VEWLNKQKPR SVIYISLGSM VLMETKEMLE MAWGMLNSNQ PFLWVIRPGS
     VSGSEGIESL PEEVSKMVLE KGYIVKWAPQ IEVLGHPSVG GFWSHCGWNS TLESIVEGVP
     MICRPYQGEQ MLNAIYLESV WRIGIQVGGE LERGAVERAV KRLIVDKEGA SMRERTLVLK
     EKLKASIRGG GSSCNALDEL VKHLKTE