ID   U79_HHV6H               Reviewed;         480 AA.
AC   Q96896; O57141; O93113; Q785M1;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   23-FEB-2022, entry version 50.
DE   RecName: Full=Protein U79/U80;
GN   Name=U79/U80;
OS   Human herpesvirus 6B (HHV-6 variant B) (Human B lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=32604;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9453140; DOI=10.1016/s0168-1702(97)00099-3;
RA   Kosuge H., Isegawa Y., Yamanishi K.;
RT   "Nucleotide sequence analysis of a 30-kilobase-pair region of human
RT   herpesvirus-6B (HHV-6B) genome and strain-specific variations in major
RT   immediate-early genes.";
RL   Virus Res. 52:1-14(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482554; DOI=10.1128/jvi.73.10.8053-8063.1999;
RA   Isegawa Y., Mukai T., Nakano K., Kagawa M., Chen J., Mori Y., Sunagawa T.,
RA   Kawanishi K., Sashihara J., Hata A., Zou P., Kosuge H., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of human herpesvirus 6 variants A
RT   and B.";
RL   J. Virol. 73:8053-8063(1999).
RN   [3]
RP   ALTERNATIVE SPLICING, AND SUBCELLULAR LOCATION.
RX   PubMed=10860885; DOI=10.1006/viro.2000.0326;
RA   Taniguchi T., Shimamoto T., Isegawa Y., Kondo K., Yamanishi K.;
RT   "Structure of transcripts and proteins encoded by U79-80 of human
RT   herpesvirus 6 and its subcellular localization in infected cells.";
RL   Virology 271:307-320(2000).
CC   -!- FUNCTION: May be involved in DNA replication. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:10860885}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1; Synonyms=clone 37;
CC         IsoId=Q96896-1; Sequence=Displayed;
CC       Name=2; Synonyms=clone 7;
CC         IsoId=Q96896-2; Sequence=VSP_034623, VSP_034624;
CC       Name=3; Synonyms=clone 27;
CC         IsoId=Q96896-3; Sequence=VSP_034622, VSP_034627;
CC       Name=4; Synonyms=clone 2;
CC         IsoId=Q96896-4; Sequence=VSP_034625, VSP_034626;
CC   -!- PTM: Not phosphorylated.
CC   -!- MISCELLANEOUS: Isoform 1 belongs to the late class proteins. Isoform 2,
CC       Isoform 3 and Isoform 4 belong to the early class proteins.
CC   -!- SIMILARITY: Belongs to the herpesviridae U79/UL112 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC40328.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAC40329.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAA78299.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAA78300.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; U92288; AAC40328.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; U92288; AAC40329.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AB021506; BAA78299.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AB021506; BAA78300.1; ALT_SEQ; Genomic_DNA.
DR   PIR; T44038; T44038.
DR   PIR; T44039; T44039.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004138; U79_P34.
DR   Pfam; PF03064; U79_P34; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Host nucleus.
FT   CHAIN           1..480
FT                   /note="Protein U79/U80"
FT                   /id="PRO_0000343650"
FT   REGION          156..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          417..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..233
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         252..322
FT                   /note="ALSPCVSIDNHEDQQHDELDKRVYAQGTNREGLSNEDNYGNFQLNKSLEQLR
FT                   ARLVASSGEVVERSLSKLK -> RYLCVRLNRLSTCEYLKLKQRRTQEEFDNGPEQPSD
FT                   QQMVQSGSSVLFQDKTGAEHEDVAEGEFPGDGIPI (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034622"
FT   VAR_SEQ         252..259
FT                   /note="ALSPCVSI -> DEPRRSIQ (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034623"
FT   VAR_SEQ         260..480
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034624"
FT   VAR_SEQ         278..282
FT                   /note="GTNRE -> VGTCV (in isoform 4)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034625"
FT   VAR_SEQ         283..480
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034626"
FT   VAR_SEQ         323..480
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034627"
SQ   SEQUENCE   480 AA;  54972 MW;  0F2CA9FE53F30C01 CRC64;
     MYAEERGYGS FDNVIQAYEQ IISQSLHLKR FEFDNGCFIE FLADSGTCET FSKGWISMIY
     WTSETDSMGS LTVDIGMDEG KCRTYRARGL LLCSKSITSI SQNTEGRERI LTVSHENGKL
     QITFVTIAKV SSEPELRNLG DLKFMEKFEK ECRALDRKKH DDEHRKRSGK QKEKRKVEDI
     DKKKEDEKLK QEEKKRNDED KRPDKKDEFD EPPKEKRQKS HHETKRNLEE QSHEDGIAPT
     STTFVNGAVE GALSPCVSID NHEDQQHDEL DKRVYAQGTN REGLSNEDNY GNFQLNKSLE
     QLRARLVASS GEVVERSLSK LKERLDYVKD NLIKNVLECA DVTVPSKCLS KTKHIEQKKQ
     IVFSDCVRSV PVCEIKPFID MRVFETETTQ NARRVRQRTR TTVGSTDGAI GQQRVISGQN
     RGRARGRGRG RVPRRRNSNL NNLRTQNSAI VIDDSSETEN FENAGSFNED LLATTILETL