ID   U79_HHV6U               Reviewed;         474 AA.
AC   P52529; Q69469; Q69563; Q76QS7;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   02-JUN-2021, entry version 60.
DE   RecName: Full=Protein U79/U80;
GN   Name=U79/U80; Synonyms=EDRF1/EDRF2;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7941342; DOI=10.1006/viro.1994.1589;
RA   Nicholas J.;
RT   "Nucleotide sequence analysis of a 21-kbp region of the genome of human
RT   herpesvirus-6 containing homologues of human cytomegalovirus major
RT   immediate-early and replication genes.";
RL   Virology 204:738-750(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- FUNCTION: May be involved in DNA replication. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=The isoforms have been deduced by homology to HHV-6B.;
CC       Name=1;
CC         IsoId=P52529-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P52529-2; Sequence=VSP_034765, VSP_034766;
CC   -!- SIMILARITY: Belongs to the herpesviridae U79/UL112 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA68470.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAA68471.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA58329.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA58371.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; U13194; AAA68470.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; U13194; AAA68471.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; X83413; CAA58329.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; X83413; CAA58371.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_042972.2; NC_001664.2.
DR   SMR; P52529; -.
DR   PRIDE; P52529; -.
DR   DNASU; 1487960; -.
DR   GeneID; 1487960; -.
DR   KEGG; vg:1487960; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004138; U79_P34.
DR   Pfam; PF03064; U79_P34; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Host nucleus; Reference proteome.
FT   CHAIN           1..474
FT                   /note="Protein U79/U80"
FT                   /id="PRO_0000116325"
FT   REGION          156..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          412..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         251..258
FT                   /note="ALPPCISI -> DEPRRSIQ (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034765"
FT   VAR_SEQ         259..474
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034766"
SQ   SEQUENCE   474 AA;  54205 MW;  077D95DC04E448E9 CRC64;
     MYAEERAYGS FDDVMEVYQQ IVTESIQLKR LHFGSGCLIE FLGDSGTCET FCGGWISMIC
     WTSDTNSMGS LTVDIGIDDG KYKTYNARGF LLCSKSITSI SQNTEGRDRI LTVSQENNKL
     QITFVTLTKV FKEHDIRNLG DPKCIEKFEK ECRALDRKKH DDEHRKRSGK QKEKRKVEDT
     DKKKDDDRRK QEERKRNDED KQPDKKEESD ELPKEKRQKY HDMKRNLEEQ SHEDGITLTS
     TTLVNGAVEG ALPPCISIDN HEDQQHDELD KRAYAQGTNR EGLSNEDNYG NFRLNKSLEQ
     LRAKLVASSG DIVERSLLKL KECLDNVKDN LIKNECADVT GPSKCLSKTK HIEPKKQIVF
     SDCVRPVPVC EIKPFIDVRL FETARSPRRL RQRTRTIVGS TDGAIEQQRV ISGQNRGRAR
     GRGRGRAPRR RNSNINNSRT QTTIVIDDSS EAENFENEGS FNEDLLATTI LETL