U7AB_CONGE
ID U7AB_CONGE Reviewed; 29 AA.
AC P05483;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Omega-conotoxins GVIIA/GVIIB;
DE AltName: Full=SNX-178;
DE AltName: Full=Shaker peptides GVIIA/GVIIB;
OS Conus geographus (Geography cone) (Nubecula geographus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Gastridium.
OX NCBI_TaxID=6491;
RN [1]
RP PROTEIN SEQUENCE, HYDROXYLATION AT PRO-4 AND PRO-7, AND SUBCELLULAR
RP LOCATION.
RX PubMed=4071055; DOI=10.1126/science.4071055;
RA Olivera B.M., Gray W.R., Zeikus R.D., McIntosh J.M., Varga J., Rivier J.E.,
RA de Santos V., Cruz L.J.;
RT "Peptide neurotoxins from fish-hunting cone snails.";
RL Science 230:1338-1343(1985).
CC -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC block voltage-gated calcium channels (Cav).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:4071055}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:4071055}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC -!- MISCELLANEOUS: The sequence shown is that of conotoxin GVIIA.
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DR PIR; A43620; A43620.
DR PIR; B43620; B43620.
DR AlphaFoldDB; P05483; -.
DR SMR; P05483; -.
DR ConoServer; 1743; GVIIA.
DR ConoServer; 2581; GVIIB.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR012321; Conotoxin_omega-typ_CS.
DR PROSITE; PS60004; OMEGA_CONOTOXIN; 1.
PE 1: Evidence at protein level;
KW Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW Hydroxylation; Ion channel impairing toxin; Knottin; Neurotoxin;
KW Presynaptic neurotoxin; Secreted; Toxin;
KW Voltage-gated calcium channel impairing toxin.
FT PEPTIDE 1..29
FT /note="Omega-conotoxins GVIIA/GVIIB"
FT /id="PRO_0000044475"
FT MOD_RES 4
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:4071055"
FT MOD_RES 7
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:4071055"
FT DISULFID 1..16
FT DISULFID 8..19
FT DISULFID 15..26
FT VARIANT 21
FT /note="L -> S (in GVIIB)"
SQ SEQUENCE 29 AA; 3290 MW; 57307C69583FB1E7 CRC64;
CKSPGTPCSR GMRDCCTSCL LYSNKCRRY
