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U85A2_ARATH
ID   U85A2_ARATH             Reviewed;         481 AA.
AC   Q9ZWJ3; C0Z2M0; Q8W4G1;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=UDP-glycosyltransferase 85A2;
DE            EC=2.4.1.-;
GN   Name=UGT85A2; OrderedLocusNames=At1g22360; ORFNames=T16E15.3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RA   Yamagishi E., Gond Z., Yamazaki M., Saito K.;
RT   "Molecular cloning of a cDNA encoding a novel VDP-Glucose
RT   glucosyltransferase homologue from Arabidopsis thaliana.";
RL   (er) Plant Gene Register PGR98-187(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA   Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA   Shinozaki K.;
RT   "Analysis of multiple occurrences of alternative splicing events in
RT   Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL   DNA Res. 16:155-164(2009).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=11042215; DOI=10.1074/jbc.m007447200;
RA   Li Y., Baldauf S., Lim E.K., Bowles D.J.;
RT   "Phylogenetic analysis of the UDP-glycosyltransferase multigene family of
RT   Arabidopsis thaliana.";
RL   J. Biol. Chem. 276:4338-4343(2001).
RN   [7]
RP   TISSUE SPECIFICITY.
RX   PubMed=17498920; DOI=10.1016/j.ygeno.2007.03.014;
RA   Woo H.H., Jeong B.R., Hirsch A.M., Hawes M.C.;
RT   "Characterization of Arabidopsis AtUGT85A and AtGUS gene families and their
RT   expression in rapidly dividing tissues.";
RL   Genomics 90:143-153(2007).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9ZWJ3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9ZWJ3-3; Sequence=VSP_041229, VSP_041230;
CC   -!- TISSUE SPECIFICITY: Expressed in roots, shoots, leaves and flowers.
CC       {ECO:0000269|PubMed:17498920}.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; AB016819; BAA34687.1; -; mRNA.
DR   EMBL; AC068562; AAF87256.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE30232.1; -; Genomic_DNA.
DR   EMBL; AF332418; AAG48781.1; -; mRNA.
DR   EMBL; AY062579; AAL32657.1; -; mRNA.
DR   EMBL; AY093357; AAM13356.1; -; mRNA.
DR   EMBL; AK318834; BAH56949.1; -; mRNA.
DR   PIR; E86356; E86356.
DR   RefSeq; NP_173653.1; NM_102086.3. [Q9ZWJ3-1]
DR   AlphaFoldDB; Q9ZWJ3; -.
DR   SMR; Q9ZWJ3; -.
DR   BioGRID; 24082; 1.
DR   STRING; 3702.AT1G22360.1; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   iPTMnet; Q9ZWJ3; -.
DR   PaxDb; Q9ZWJ3; -.
DR   PRIDE; Q9ZWJ3; -.
DR   ProteomicsDB; 228734; -. [Q9ZWJ3-1]
DR   EnsemblPlants; AT1G22360.1; AT1G22360.1; AT1G22360. [Q9ZWJ3-1]
DR   GeneID; 838843; -.
DR   Gramene; AT1G22360.1; AT1G22360.1; AT1G22360. [Q9ZWJ3-1]
DR   KEGG; ath:AT1G22360; -.
DR   Araport; AT1G22360; -.
DR   TAIR; locus:2196501; AT1G22360.
DR   eggNOG; KOG1192; Eukaryota.
DR   HOGENOM; CLU_001724_0_0_1; -.
DR   InParanoid; Q9ZWJ3; -.
DR   OMA; WREKAIM; -.
DR   OrthoDB; 508327at2759; -.
DR   PhylomeDB; Q9ZWJ3; -.
DR   BioCyc; ARA:AT1G22360-MON; -.
DR   PRO; PR:Q9ZWJ3; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9ZWJ3; baseline and differential.
DR   Genevisible; Q9ZWJ3; AT.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; ISS:TAIR.
DR   GO; GO:0080043; F:quercetin 3-O-glucosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0080044; F:quercetin 7-O-glucosyltransferase activity; IBA:GO_Central.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..481
FT                   /note="UDP-glycosyltransferase 85A2"
FT                   /id="PRO_0000409126"
FT   BINDING         303
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   BINDING         360..362
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   BINDING         377..385
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   BINDING         399..402
FT                   /ligand="UDP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:58885"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         425..427
FT                   /note="REE -> SEE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:19423640"
FT                   /id="VSP_041229"
FT   VAR_SEQ         428..481
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:19423640"
FT                   /id="VSP_041230"
FT   CONFLICT        191
FT                   /note="N -> D (in Ref. 4; AAL32657/AAM13356)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        219
FT                   /note="D -> N (in Ref. 4; AAL32657/AAM13356)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   481 AA;  54364 MW;  6B96A6314AE1C324 CRC64;
     MGSHVAQKQH VVCVPYPAQG HINPMMKVAK LLYAKGFHIT FVNTVYNHNR LLRSRGPNAV
     DGLPSFRFES IPDGLPETDV DVTQDIPTLC ESTMKHCLAP FKELLRQINA RDDVPPVSCI
     VSDGCMSFTL DAAEELGVPE VLFWTTSACG FLAYLYYYRF IEKGLSPIKD ESYLTKEHLD
     TKIDWIPSMK NLRLKDIPSF IRTTNPDDIM LNFIIREADR AKRASAIILN TFDDLEHDVI
     QSMKSIVPPV YSIGPLHLLE KQESGEYSEI GRTGSNLWRE ETECLDWLNT KARNSVVYVN
     FGSITVLSAK QLVEFAWGLA ATGKEFLWVI RPDLVAGDEA MVPPEFLTAT ADRRMLASWC
     PQEKVLSHPA IGGFLTHCGW NSTLESLCGG VPMVCWPFFA EQQTNCKFSR DEWEVGIEIG
     GDVKREEVEA VVRELMDEEK GKNMREKAEE WRRLANEATE HKHGSSKLNF EMLVNKVLLG
     E
 
 
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