ID   UAP1L_DANRE             Reviewed;         505 AA.
AC   Q7ZWD4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=UDP-N-acetylhexosamine pyrophosphorylase-like protein 1;
DE            EC=2.7.7.-;
GN   Name=uap1l1; ORFNames=zgc:56509;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UDPGP type 1 family. {ECO:0000305}.
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DR   EMBL; BC049467; AAH49467.1; -; mRNA.
DR   RefSeq; NP_956588.1; NM_200294.1.
DR   AlphaFoldDB; Q7ZWD4; -.
DR   SMR; Q7ZWD4; -.
DR   STRING; 7955.ENSDARP00000025374; -.
DR   PaxDb; Q7ZWD4; -.
DR   PRIDE; Q7ZWD4; -.
DR   GeneID; 393264; -.
DR   KEGG; dre:393264; -.
DR   CTD; 91373; -.
DR   ZFIN; ZDB-GENE-040426-1056; uap1l1.
DR   eggNOG; KOG2388; Eukaryota.
DR   InParanoid; Q7ZWD4; -.
DR   OrthoDB; 888726at2759; -.
DR   PhylomeDB; Q7ZWD4; -.
DR   PRO; PR:Q7ZWD4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0003977; F:UDP-N-acetylglucosamine diphosphorylase activity; IBA:GO_Central.
DR   GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR039741; UDP-sugar_pyrophosphorylase.
DR   InterPro; IPR002618; UDPGP_fam.
DR   PANTHER; PTHR11952; PTHR11952; 1.
DR   Pfam; PF01704; UDPGP; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..505
FT                   /note="UDP-N-acetylhexosamine pyrophosphorylase-like
FT                   protein 1"
FT                   /id="PRO_0000324582"
FT   MOTIF           110..113
FT                   /note="Substrate binding"
FT   MOTIF           305..306
FT                   /note="Substrate binding"
FT   BINDING         110..113
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         124
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         198
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         224
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         225
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         255
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         379
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         409
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   505 AA;  56414 MW;  D5113AD734A4E85A CRC64;
     MSFEEAKAKL EAAGQTHVLQ FWDELSAEER GTFLEEISQL QPDELVEHCR EAAASASRHS
     SADGRLDARM QPVPPEFIGS VRKSDRETLQ KWENEGLLQI SQDRVAVLLL AGGQGTRLGV
     SYPKGMYNVG LPSGKTLYQI QAERIQKVQE LANVRHGCRC TVPWYIMTSE FTLGPTEKFF
     KDNKYFGLCP SNVVMFEQRM IPAVGFDGKI ILEKKNKIAM APDGNGGLYR SLVDNKILAD
     MERRNVEFLH VYCVDNILVK MADPVFIGFC VTNGADCGAK VVEKAYPAEP VGVVCRVDGV
     YQVIEYSEIQ PETAELRGSG GELVFSAGNI CNHFFTRSFL RDVAEKFESK LKQHVAIKKV
     PFVDGEGNLV KPTKPNGIKM EKFVFDVFQF SKKFVAFEVL REEEFSPLKN ADGAPLDTPT
     TARRSLLAQH YRWILAAGGS FLDEQNKPFT PKHSTAQIED PPAVCEISPL VSYFGEGLEM
     LLNQKNLKSP FILDENEAKN LVHTV