UAP1L_MOUSE
ID UAP1L_MOUSE Reviewed; 507 AA.
AC Q3TW96; A1L3D3; Q6KAP8; Q6NVB6; Q80XP4;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=UDP-N-acetylhexosamine pyrophosphorylase-like protein 1;
DE EC=2.7.7.-;
GN Name=Uap1l1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Amnion, and Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 3-507 (ISOFORM 1).
RC STRAIN=Czech II, and FVB/N; TISSUE=Kidney, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-477 (ISOFORM 1).
RC TISSUE=Spleen;
RX PubMed=15449545; DOI=10.1093/dnares/11.2.127;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of FLJ genes: the
RT complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified
RT by screening of terminal sequences of cDNA clones randomly sampled from
RT size-fractionated libraries.";
RL DNA Res. 11:127-135(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3TW96-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TW96-2; Sequence=VSP_032281;
CC -!- SIMILARITY: Belongs to the UDPGP type 1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH43307.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAD21409.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence={ECO:0000305};
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DR EMBL; AK151942; BAE30818.1; -; mRNA.
DR EMBL; AK159787; BAE35370.1; -; mRNA.
DR EMBL; AK168977; BAE40778.1; -; mRNA.
DR EMBL; AL732557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC043307; AAH43307.1; ALT_INIT; mRNA.
DR EMBL; BC068207; AAH68207.1; -; mRNA.
DR EMBL; BC130030; AAI30031.1; -; mRNA.
DR EMBL; AK131159; BAD21409.1; ALT_SEQ; Transcribed_RNA.
DR CCDS; CCDS15767.1; -. [Q3TW96-1]
DR RefSeq; NP_001028465.1; NM_001033293.2. [Q3TW96-1]
DR AlphaFoldDB; Q3TW96; -.
DR SMR; Q3TW96; -.
DR BioGRID; 230646; 4.
DR IntAct; Q3TW96; 1.
DR MINT; Q3TW96; -.
DR STRING; 10090.ENSMUSP00000099989; -.
DR iPTMnet; Q3TW96; -.
DR PhosphoSitePlus; Q3TW96; -.
DR SwissPalm; Q3TW96; -.
DR EPD; Q3TW96; -.
DR jPOST; Q3TW96; -.
DR MaxQB; Q3TW96; -.
DR PaxDb; Q3TW96; -.
DR PeptideAtlas; Q3TW96; -.
DR PRIDE; Q3TW96; -.
DR ProteomicsDB; 298345; -. [Q3TW96-1]
DR ProteomicsDB; 298346; -. [Q3TW96-2]
DR Antibodypedia; 52196; 82 antibodies from 18 providers.
DR Ensembl; ENSMUST00000102925; ENSMUSP00000099989; ENSMUSG00000026956. [Q3TW96-1]
DR GeneID; 227620; -.
DR KEGG; mmu:227620; -.
DR UCSC; uc008irr.1; mouse. [Q3TW96-1]
DR CTD; 91373; -.
DR MGI; MGI:2443318; Uap1l1.
DR VEuPathDB; HostDB:ENSMUSG00000026956; -.
DR eggNOG; KOG2388; Eukaryota.
DR GeneTree; ENSGT00940000153464; -.
DR HOGENOM; CLU_025603_1_0_1; -.
DR InParanoid; Q3TW96; -.
DR OMA; KGMYRVG; -.
DR OrthoDB; 888726at2759; -.
DR PhylomeDB; Q3TW96; -.
DR TreeFam; TF300611; -.
DR BioGRID-ORCS; 227620; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Uap1l1; mouse.
DR PRO; PR:Q3TW96; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q3TW96; protein.
DR Bgee; ENSMUSG00000026956; Expressed in epithelium of small intestine and 185 other tissues.
DR Genevisible; Q3TW96; MM.
DR GO; GO:0003977; F:UDP-N-acetylglucosamine diphosphorylase activity; IBA:GO_Central.
DR GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR039741; UDP-sugar_pyrophosphorylase.
DR InterPro; IPR002618; UDPGP_fam.
DR PANTHER; PTHR11952; PTHR11952; 1.
DR Pfam; PF01704; UDPGP; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Nucleotidyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..507
FT /note="UDP-N-acetylhexosamine pyrophosphorylase-like
FT protein 1"
FT /id="PRO_0000324581"
FT MOTIF 111..114
FT /note="Substrate binding"
FT MOTIF 306..307
FT /note="Substrate binding"
FT BINDING 111..114
FT /ligand="UTP"
FT /ligand_id="ChEBI:CHEBI:46398"
FT /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT BINDING 125
FT /ligand="UTP"
FT /ligand_id="ChEBI:CHEBI:46398"
FT /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT BINDING 199
FT /ligand="UTP"
FT /ligand_id="ChEBI:CHEBI:46398"
FT /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT BINDING 225
FT /ligand="UTP"
FT /ligand_id="ChEBI:CHEBI:46398"
FT /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT BINDING 226
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 256
FT /ligand="UTP"
FT /ligand_id="ChEBI:CHEBI:46398"
FT /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT BINDING 380
FT /ligand="UTP"
FT /ligand_id="ChEBI:CHEBI:46398"
FT /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT BINDING 410
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..126
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032281"
SQ SEQUENCE 507 AA; 56614 MW; F4972BE7DBA6C1A1 CRC64;
MDSERDVRAQ LQRAGQDHLL RFYADLAPEA RAALLAELAS LEADALREHC QRAAAAGALA
PGPLPDLAAR LQPLPPERVG SAIRCDQETR LRWEEEGFRQ ISLNKVAVLL LAGGQGTRLG
VTYPKGMYQV GLPSQKTLYQ LQAERIRRVQ QLADQRQGTH CTVPWYIMTS EFTLGPTIKF
FKEHDFFHLD PTNVVLFEQR MLPAVTFEGK AILERKDKVA MAPDGNGGLY CALADHQILE
DMKQRGVEFV HVYCVDNILV RLADPVFIGF CVLQGADCGA KVVEKAYPEE PVGVVCQVDG
VPQVVEYSEI SPEIAGQLGA DGGLLYNAGN ICNHFFTRGF LDVVTREFEP LLRLHVAMKK
VPYVDEEGNL VKPLRPNGIK MEKFVFDVFQ FAKNFVAFEV CREEEFSPLK NDDTADRDNP
STCRRALLAQ HYRWALQAGA RFLDVHGVQL TEQSGMLPNG DPPAICEISP LVSYSGEGLE
MYLQGRQLQS PFILDEDQAR LLRPQDC
