ID   UAP1L_XENTR             Reviewed;         511 AA.
AC   Q28CH3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=UDP-N-acetylhexosamine pyrophosphorylase-like protein 1;
DE            EC=2.7.7.-;
GN   Name=uap1l1; ORFNames=TGas075i06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the UDPGP type 1 family. {ECO:0000305}.
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DR   EMBL; CR926388; CAJ83512.1; -; mRNA.
DR   RefSeq; NP_001015926.1; NM_001015926.2.
DR   AlphaFoldDB; Q28CH3; -.
DR   SMR; Q28CH3; -.
DR   GeneID; 548680; -.
DR   KEGG; xtr:548680; -.
DR   CTD; 91373; -.
DR   Xenbase; XB-GENE-1002718; uap1l1.
DR   InParanoid; Q28CH3; -.
DR   OrthoDB; 888726at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0003977; F:UDP-N-acetylglucosamine diphosphorylase activity; IBA:GO_Central.
DR   GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR039741; UDP-sugar_pyrophosphorylase.
DR   InterPro; IPR002618; UDPGP_fam.
DR   PANTHER; PTHR11952; PTHR11952; 1.
DR   Pfam; PF01704; UDPGP; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Nucleotidyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..511
FT                   /note="UDP-N-acetylhexosamine pyrophosphorylase-like
FT                   protein 1"
FT                   /id="PRO_0000324583"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           117..120
FT                   /note="Substrate binding"
FT   MOTIF           312..313
FT                   /note="Substrate binding"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         117..120
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         131
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         205
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         231
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         232
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         262
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         386
FT                   /ligand="UTP"
FT                   /ligand_id="ChEBI:CHEBI:46398"
FT                   /evidence="ECO:0000250|UniProtKB:Q9M9P3"
FT   BINDING         416
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   511 AA;  57299 MW;  BDC3AEE3331D98BD CRC64;
     MDRSESAESA ESRRRRAEES GQGQLFRFWD ELSPAEKEAL LEQLEMLEPR ELREHCQRAR
     EAYVRESSAP QRLDDRMQPV PPEFLGSVRH SGTGELERWE REGFHQIAQN KVAVLLLAGG
     QGTRLGVTYP KGMYSVGLPS AKTLYQIQAE RIRRLQQLAS ERHGETCTVP WYIMTSEFTL
     GPTRKFFEDH AYFGLERSDV VMFEQRMLPA VGFDGAAILE DKAKLAMAPD GNGGLYRALS
     DNRILEDMEG RGIQYVHVYC VDNILVKMAD PVFIGFCVSK GADCGAKVVE KGYPAEPVGV
     VCRVDGVYQV VEYSEISPET AEKRNPNGAL TFTAGNICNH FFTVPFLRAV IGSLEPRLNY
     HVAIKKVPYV DNEGNLVKPT SPNGIKMEKF VFDVFQFAKN FVAFEVLREE EFSPLKNADT
     ADKDTPTTAR RALLWQHYRW ARRAGTHFLD ETGSPIRDSH SISGEGDPPA VCEISPLVSY
     FGEGLESYMK DKDVSSFPFV LESSDAGPVP V