UAPC_EMENI
ID UAPC_EMENI Reviewed; 580 AA.
AC P48777; C8V1W9; Q5AYA0;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Purine permease;
GN Name=uapC; ORFNames=AN6730;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7721763; DOI=10.1074/jbc.270.15.8610;
RA Diallinas G., Gorfinkiel L., Arst H.N. Jr., Cecchetto G., Scazzocchio C.;
RT "Genetic and molecular characterization of a gene encoding a wide
RT specificity purine permease of Aspergillus nidulans reveals a novel family
RT of transporters conserved in prokaryotes and eukaryotes.";
RL J. Biol. Chem. 270:8610-8622(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Able to transport with low efficiency all natural purines as
CC well as purine analogs.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- INDUCTION: Inducible by 2-thiouric acid, and highly repressible by
CC ammonium.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000305}.
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DR EMBL; X79796; CAA56190.1; -; Genomic_DNA.
DR EMBL; AACD01000112; EAA58548.1; -; Genomic_DNA.
DR EMBL; BN001301; CBF71344.1; -; Genomic_DNA.
DR PIR; A56382; A56382.
DR RefSeq; XP_664334.1; XM_659242.1.
DR AlphaFoldDB; P48777; -.
DR SMR; P48777; -.
DR STRING; 162425.CADANIAP00007522; -.
DR TCDB; 2.A.40.4.4; the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.
DR EnsemblFungi; CBF71344; CBF71344; ANIA_06730.
DR EnsemblFungi; EAA58548; EAA58548; AN6730.2.
DR GeneID; 2870356; -.
DR KEGG; ani:AN6730.2; -.
DR VEuPathDB; FungiDB:AN6730; -.
DR eggNOG; ENOG502QQD4; Eukaryota.
DR HOGENOM; CLU_017959_7_0_1; -.
DR InParanoid; P48777; -.
DR OMA; RKSAPFF; -.
DR OrthoDB; 387031at2759; -.
DR Proteomes; UP000000560; Chromosome I.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0000324; C:fungal-type vacuole; IDA:AspGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:AspGD.
DR GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; IMP:AspGD.
DR GO; GO:0042907; F:xanthine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006863; P:purine nucleobase transport; IMP:AspGD.
DR GO; GO:0042906; P:xanthine transport; IBA:GO_Central.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR TIGRFAMs; TIGR00801; ncs2; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..580
FT /note="Purine permease"
FT /id="PRO_0000165953"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 426..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 151
FT /note="A -> G (in Ref. 1; CAA56190)"
FT /evidence="ECO:0000305"
FT CONFLICT 416
FT /note="R -> P (in Ref. 1; CAA56190)"
FT /evidence="ECO:0000305"
FT CONFLICT 569
FT /note="S -> C (in Ref. 1; CAA56190)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 580 AA; 61349 MW; 8F3B8F9BF6C129CF CRC64;
MDGPDQIGPD VRPRRTFGDR VRRAARAFTT RDGLIGDYDY GFLFTPRLPF VKQKRRAAPF
FGLEDKIPLV LALLLGLQHA LAMLAGVITP PILLAGSSGA NFGADESQYL VSTSLIVSGL
LSAVQMFRLH VYKTRYYVGT GLVSVVGTSF ATITVATGTF NQMYSTGYCP VDGSGNRLPC
PKGYGALLAT SCLCSLLEIG LSFMSSRLLK ALFPPIVTGP TVFLIGASLI GNAMKDWAGG
SGTCSSNPGN GALCPSADAP HPLPWGSAEF IGLGFLVFAT IILCERFGSP IMKSCAVIVG
LLVGCIVAAA CGYFDRSGID AAPVASFIWV KTFPLTIYAP LILPLLAVYM VIMMESIGDI
TATCDVSRLQ VEGATFDSRI QGGVLGNGIT CLLAGLCTIT PMSVFAQNNG VIALTRCANR
KAGYCCCFFL VVMGIFAKFA AALVAIPSSV LGGMTTFLFS SVAISGVRIM CSVDWTRRNR
FILTASFAVG MAATLVPDWF SYFFTYSGDN HALEGLLQAV ELVMANGFAV TGFLGLLLNL
ILPEDMEEDV VESEEDYEAT TVVGMQGGSE PGSSGQNVKA
