ID   UAY_EMENI               Reviewed;        1060 AA.
AC   P49413; C8VUT2; Q5BEY9;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Positive regulator of purine utilization;
GN   Name=uaY; ORFNames=AN0891;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7729421; DOI=10.1002/j.1460-2075.1995.tb07132.x;
RA   Suarez T., Vieira de Queiroz M., Oestreicher N., Scazzocchio C.;
RT   "The sequence and binding specificity of UaY, the specific regulator of the
RT   purine utilization pathway in Aspergillus nidulans, suggest an evolutionary
RT   relationship with the PPR1 protein of Saccharomyces cerevisiae.";
RL   EMBO J. 14:1453-1467(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Mediates the induction of a number of unlinked genes involved
CC       in purine utilization. Binds to the consensus sequence 5'-
CC       TCGGNNNNNNCCGA-3'.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; X84015; CAA58838.1; -; Genomic_DNA.
DR   EMBL; AACD01000014; EAA65920.1; -; Genomic_DNA.
DR   EMBL; BN001308; CBF88580.1; -; Genomic_DNA.
DR   PIR; S54779; S54779.
DR   RefSeq; XP_658495.1; XM_653403.1.
DR   AlphaFoldDB; P49413; -.
DR   SMR; P49413; -.
DR   STRING; 162425.CADANIAP00001766; -.
DR   EnsemblFungi; CBF88580; CBF88580; ANIA_00891.
DR   EnsemblFungi; EAA65920; EAA65920; AN0891.2.
DR   GeneID; 2876671; -.
DR   KEGG; ani:AN0891.2; -.
DR   VEuPathDB; FungiDB:AN0891; -.
DR   eggNOG; ENOG502QR1M; Eukaryota.
DR   HOGENOM; CLU_004517_0_0_1; -.
DR   InParanoid; P49413; -.
DR   OMA; WCVYSFD; -.
DR   OrthoDB; 545687at2759; -.
DR   Proteomes; UP000000560; Chromosome VIII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:AspGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:AspGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006145; P:purine nucleobase catabolic process; IMP:AspGD.
DR   GO; GO:0010468; P:regulation of gene expression; IMP:AspGD.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:AspGD.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..1060
FT                   /note="Positive regulator of purine utilization"
FT                   /id="PRO_0000114985"
FT   DNA_BIND        67..94
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          251..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          811..862
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          876..969
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..382
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        811..852
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        892..906
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        928..947
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        449
FT                   /note="A -> R (in Ref. 1; CAA58838)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        476
FT                   /note="R -> A (in Ref. 1; CAA58838)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        497
FT                   /note="R -> A (in Ref. 1; CAA58838)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        984..985
FT                   /note="QL -> HV (in Ref. 1; CAA58838)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1060 AA;  118391 MW;  4ED64081BC4EAA8A CRC64;
     MLNPSTSDIH TSPTAVGNGR KRPHPIADSG SAMPSDPSAQ QLPHPANESA AIPSIASSSS
     FRNVSACNRC RQRKNRCDQR LPRCQACEKA GVRCVGYDPI TKREIPRSYV YFLESRVAYL
     EKVLMDNGIE YNEAVAFDEE EAVKIEAGYE AYAGSANGPA AGEIAAQDGS NDKSVRIKKE
     KNGPLGLEKA SRYDHDPEVK QDSDAEDGWR IQNLVSNIGM VSVQGTSDPR YLGSTSGISF
     ARVVFAAVKS SVPGNSSERG PSRPKERLPH SATGTEGSTT RDSFFGLQTR PMMKCAAFPD
     RELAERLADL YFEHANPQIP IVHRVDFMEL LDRTYSVDEK SRSPRSLYFL NIVFAIGSGI
     IFEDKPAEDQ KEGRDHSPSA TKRQRLSSRQ YQPEEYHASA IVHLESFLST SPTTDGFGAL
     EELQAVLLLA SFALLRPVAP GLWYIVGVAM RLAVDLGLHY EDGAGIDGPE NDNMNRTNNK
     DGEKAKLRID DHERGRREWV RDFRRRLWWC CYSFDRLVSC CVGRPFGISD QAISTEFPSI
     LEDKYITKSG IIKAPEGAPS YKHSAFHYFK LRVLQSEIQD VLQHQQARFA RQRGPPGARS
     FMRLDVVSPF LQGFDSFRSW RRDVDRRLLE WKNSAPMPSE NGVRFPLEFL ELNYWQAVIM
     LYQQSLTVPA ELADELSPAE DVSSPSFSQV EEDEHDIYYK VAEAGQKVIR IYRQMHRVRL
     VNYTYLATHH IFMAGISFLY AIWHSPYVRS RLTLDEVDFT VLAATSVLRD LMHKCPPAEA
     CRDAFERMSK ATVEMSLSTT GFGPQVELNR VQTSTSGSRQ FNATQSRSRP YSRQQAEQRQ
     RQSASRRQLQ MRQSRPLPRF DMNLEDLFGD NRAVAERQGS GGMGKLAQPY PVSETSDPNF
     ARPQSHRNPS MEYYGPFENP VSPQQPQPQP RYYYNNSPQQ SGSPGSVVAA SGIPPYQVTP
     TEQENPSGMG LDYLDYDPTG IERQLSLGSE ENSDFKFQGG AQSLGHGAGH NFGIDLGFGM
     AVDFQHDWSE NANYDLLEGY FFGGAGATGP GHGHGHGSGI